Genetic and functional analysis of CCDC88C mutations in patients with Parkinson’s disease.
Objective: To investigate the association between rare deleterious CCDC88C variants and PD. Background: SCA40 is a rare form of spinocerebellar ataxia caused by heterozygous mutations…Silencing of hypoxia-inducible factor 1 alpha provokes a neuroprotective response in a SH-SY5Y model of Parkinson’s Disease.
Objective: Our study aims to delineate the role of HIF1α in a SH-SY5Y model of Parkinson’s disease (PD) Background: Parkinson’s disease (PD) is one of…Profile of miRNA expression in CSF of Parkinson’s disease identifies miR-409-3p regulating the apoptosis of dopamine neurons
Objective: To improve the precise diagnosis of PD at early stage requires more feasible and objective methods. MicroRNA (miRNA) was believed to be a potential…Chlorogenic acid attenuates the MPTP induced apoptosis in Parkinson’s disease mouse model through pAkt signaling pathway
Objective: This study deals to investigate and explore the anti-apoptotic and molecular mechanisms of CGA in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonian mice model. Background: The debilitating…Dysregulated long non-coding RNA in Parkinson’s disease contributes to the apoptosis of dopaminergic neuron
Objective: The study aims to explore the expression profiles of lncRNA of PD patients and its roles to the pathogenesis of PD. Background: The molecular…Neuroprotective effect of Lemon oil on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway
Objective: The objective of current investigation was to decipher e the neuroprotective effect of lemon oil (LO) on PC 12 cell lines by 6-hydroxydopamine (6-OHDA)…Risk of developing the Parkinson’s disease against the background of diabetes mellitus type 2.
Objective: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. Background: Parkinson’s disease is a chronic disorder in which…Evaluation of nigral neuronal apoptosis during postnatal development and adulthood of mice strains with differential sensitivity to MPTP
Objective: Compare nigral neurons in C57BL/6J, CD-1 and their F1 crossbreds with respect to developmental apoptosis in the nigra during postnatal and to assess MPTP-induced…Molecular mechanisms of GCH1-associated Parkinson’s disease
Objective: To unravel the molecular mechanisms by which loss of GCH1 function enhances the risk of Parkinson´s disease (PD). Background: Loss-of-function mutations in GCH1 are…Neuroprotective effect of exogenous melatonin on apoptosis of neuroadernergic neurons in a rat model of Parkinson’s disease
Objective: To investigate melatonin therapeutic potential effects in Parkinson’s disease. Background: Sleep disorders constitute major nonmotor features of Parkinson’s disease (PD) that have a substantial…