Honey prevented MPTP-induced oxidative stress, neuroinflammation and gliosis in adult male Swiss mice.
Objective: To investigate the neuroprotective role of honey against oxidative stress and neuroinflammation induced by MPTP in adult male Swiss mice. Background: Oxidative stress and…LRRK2 G2019S as a trigger of inflammatory signaling in patient-derived microglia
Objective: This study explores the inflammatory processes in leucine-rich repeat kinase 2 (LRRK2)- microglia carrying the G2019S mutation and determines their contribution to Parkinson’s disease…Preliminary evidence for evolution of myoinositol and N-acteylaspartate as biomarkers of disease severity in early-stage multiple system atrophy
Objective: To quantify the longitudinal evolution of metabolic indicators of gliosis and neuronal integrity in patients with multiple system atrophy (MSA) over one year. Background:…Level of glial neurotrophic factor in the blood plasma depending on the duration of Parkinson’s disease
Objective: To study the level of glial neurotrophic factor in the blood plasma depending on the duration of PD. Background: Study of the biochemical aspects…The level of glial neurotrophic factor in blood plasma depending on the stage of Parkinson’s disease
Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) depending on the stage Background: Parkinson's disease…The cross-talk between microglia-derived exosomes and brain printing biometrics as a diagnostic approach for Parkinson’s disease prior to motor symptoms implications
Objective: To highlight the efficiency of using microglia-derived exosomes (MDEs) in cross-talk with the BPB technique for the early diagnosis of Parkinson’s disease (PD) Background:…Aerobic glycolysis regulates microglia-mediated neuroinflammation by promoting H3K9 lactylation in Parkinson’s disease
Objective: This study aims to investigate the role of histone lactylation in microglia-mediated neuroinflammation and dopaminergic (DA) neuronal damage in Parkinson’s disease (PD). Background: Augmented glycolysis induced by metabolic…mGlu3 receptors in Parkinson’s disease as a candidate target for neuroprotective therapy: evidence from preclinical studies to human genetic.
Objective: In a toxicological model of mouse parkinsonism through chronic injection of MPTP, we examined whether the presence or absence of mGlu3 receptors affected neurodegeneration…Changes in the level of glial neurotrophic factor in Parkinson’s disease depending on the form
Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) depending on the form Background: Neurotrophic factors…Investigating inflammatory mechanisms in iPSC-derived LRRK2 microglia
Objective: To characterize microglial function and inflammatory mechanisms in LRRK2-associated Parkinson’s disease (PD). Background: PD is a neurodegenerative disease affecting primarily dopaminergic neurons of the…