Objective: Reporting exceptional etiology of OMS and  remembering  spectrum of neurological manifestations of rubella.

Background: Opsoclonus-myoclonus-ataxia (OMS) is a rare child clinical paraneoplastic syndrome. OMS has been less described in adult. Association with infectious and post-infectious has been recently reported. Rubella has been exceptionally reported as an etiology of OMS.

Method: Reports case for medical teaching.

Results: CASE REPORTS: We report two cases of 31 and 27-year-old young men who presented with gait disorder associated to movement disorders of limbs and eyes preceded by a febrile rash and retroauricular lymph nodes in the first case. Headache, vertigo, nausea and vomiting  had been reported in the two cases. On examination, the two patients had OMS syndrome. Brain MRI, total body scan, MIBG scintigraphy, tumor markers and onconeural antibodies were normal in the two patients. Lymphocytic meningitis analysis with positive serum and cerebro-spinal fluid immunoglobulin M antibody against rubella virus had been showed in the  two cases.  Full recovery had been obtained in one month  under acyclovir and immunoglobulin.

Conclusion: Those reports enlarge the etiology of OMS etiologies and the spectrum of neurological manifestations of rubella. Association rubella infection to OMS with full recovery under acyclovir and immunoglobulin supported infectious and post-infectious hypothesis process.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/opsoclonus-myoclonus-ataxia-syndrome-associated-to-rubella/