Objective: To study of the extent of cognitive impairment in PD patients with Covid-19.

Background: Covid-19 may aggravate the clinical course of Parkinson’s disease (PD) by affecting non-motor disorders. Cognitive impairment is one of the most common nonmotor impairments in the disease.

Method: We examined 44 patients with PD aged 36 to 68 years (mean age 52.0±4.6), including 22 men and 22 women. All patients underwent a clinical-neurological and neuropsychological examination. All patients were re-examined before and after exposure to Covid-19. The obtained results were compared.

Results: Cognitive impairment was observed in 38 patients (86.4%) before infection with Covid-19. When analyzing the level of cognitive impairment, 26 patients (68.4%) had mild cognitive impairment, 8 patients (21.1%) had moderate cognitive impairment, and 4 patients (10.5%) had severe cognitive impairment. Cognitive impairment was observed in all patients after infection with Covid-19. When analyzing the level of cognitive impairment, 21 patients (47.7%) had mild cognitive impairment, 14 patients (31.8%) had moderate cognitive impairment, and 9 patients (20.5%) had severe cognitive impairment. When the gender characteristics of the patients were studied, moderate and severe cognitive impairment was mainly observed in women. If cognitive impairment is corrected in time, the clinical course of the disease will be alleviated and the quality of life of patients will improve.

Conclusion: Covid-19 infection can exacerbate non-motor impairments, including cognitive impairment, in patients with Parkinson’s disease. If cognitive impairment is corrected in time, the clinical course of the disease will be alleviated and the quality of life of patients will improve.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/extent-of-cognitive-impairment-in-parkinsons-disease-with-covid-19/