Objective: We intended to find the frequency of Single Nucleotide Polymorphism (SNP) rs6280 in DRD3 gene in PD patients with and without Levodopa Induced Dyskinesia and their association with clinical severity. We also observed for any clinical association with genotypes.

Background: Pathogenesis of L-dopa induced dyskinesia (LID) is complex and expected to have a genetic link. Due to lack of robust evidence, we take the initiative to study the probable association of DRD3 gene SNPs in Eastern Indian Parkinson’s Disease (PD) population.

Method: 100 PD patients with LID, 100 PD patients without LID and 20 healthy subjects were recruited and blood DNA was isolated by commercially available DNA isolation kit. PCR followed by RFLP analysis were performed to find the presence of mutant alleles in the study participants. MDS-UPDRS, AIMS were performed to estimate the motor severity and dyskinesia respectively. MoCA and BDI-II were administered to evaluate cognition and depression respectively.

Results: Clinical and demographic profile were comparable in these two groups. We observed a mutant allele (G) of DRD3 gene in 30% of PD patients with LID and 43% of PD patients without LID (OR 0.56, p=0.009). UPDRS & LEDD scores were significantly different between PD with and without LID for AG+GG genotypes (p= 0.03, 0.00 respectively). Whereas both MOCA and AIMS varied significantly between these two groups for both AA and AG+GG genotypes.

Conclusion: It is possible that presence of less mutant alleles among LID patients is protective against Dyskinesia and clinical parameters may get influenced by genotypes.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/dopamine-receptor-gene-polymorphism-in-l-dopa-induced-dyskinesia-a-study-from-eastern-india/