Objective:

To investigate the impact of motor and non-motor changes on the functionality of individuals with Parkinson’s disease

Background: Parkinson’s disease (PD) is the second most common neurodegenerative condition. Its clinical diagnosis relies primarily on motor symptoms like resting tremor, limb stiffness, bradykinesia, and postural instability, known as the cardinal signs of PD. Alongside motor symptoms, patients also endure non-motor symptoms (NMS) such as constipation, urinary dysfunction, depression, psychosis, apathy, sleep disorders, and fatigue. The World Health Organization (WHO) has developed the World Health Organization Disability Assessment Schedule (WHODAS 2.0) to assess the impact of health conditions on individuals’ functionality transculturally, based on the conceptual framework of the International Classification of Functioning, Disability, and Health (ICF). WHODAS 2.0 aims to comprehend the challenges individuals face due to their health condition in the last 30 days, grouping cognition domains that evaluate communication and reasoning activities such as concentration, memory, problem-solving, learning, and communication. Recognizing symptoms, diagnosing the disease, and early intervention are increasingly urgent and vital public health concerns as PD affects individuals’ functionality.

Method:

This study included 26 individuals with idiopathic Parkinson’s disease recruited from healthcare service users at the Central Institute of the Hospital das Clínicas via telephone or WhatsApp. Participants, mostly male and white, aged 42-80 years, had completed high school. Disease severity, mainly stage 3 according to Hoen & Yahr classification, was assessed using MoCA, WHODAS 2.0, and UPDRS.

Results: The multiple linear regression model, including diagnosis time, H&Y stage, and UPDRS sections I, II, and IV, revealed that the score in section II could predict over 50% of the variability in the total WHODAS II score R = 0.76; R² = 0.59; adjusted R = 0.56; F(1,18) = 26.03; p < 0.00007).

Conclusion: Thus, this study suggests that performance in activities of daily living significantly influences the functionality of individuals with Parkinson’s Disease, as assessed by the WHODAS 2.0 scale. This finding appears to be closely linked to motor symptoms and disease staging, as per the Hoen & Yahr criteria outlined in the UPDRS.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/assessment-of-motor-and-non-motor-alterations-impacting-functionality-in-parkinsons-disease-patients/