Category: Parkinson's Disease: Neuroimaging
Objective: To assess the relationship between loss of CVR and T2DM in patients with Idiopathic PD.
Background: The relationship between cerebral vascular disease (CVD) and Parkinson’s disease (PD) has been explored, but a direct relationship has yet to be proven. Both share risk factors like increasing age and type 2 diabetes mellitus (T2DM). Furthermore, DM in patients with PD has been associated with worse motor impairment (particularly axial), less response to dopaminergic drugs, and increased risk for cognitive impairment. Cerebral Vasoreactivity (CVR) measured by Transcranial Doppler Ultrasound (TCD) is a non-invasive marker of CVD, which has been reported impaired in patients with PD. However, the influence of T2DM on CVR in PD has not been evaluated.
Method: Consecutive patients with PD from the movement disorders clinic were recruited. Demographic and clinical information was obtained from medical records. CVR was assessed using TCD, with measurements taken at baseline and 5 minutes following inhalation of 6-7% CO2. Patients were classified according to the presence of T2DM, and clinical rating scales scores (MDS-UPDRS, H&Y, MOCA, PDQ-8, NMSS) were compared between groups.
Results: We included 43 patients, 26 patients (60.5% ) were males with a median age 66 years (IQR 56-68) mean disease duration of 8 years, BMI median was 25.56 (IQR 22.89-29.33) . We found that 11 (25.6 %) had T2DM, these had higher glucose level median 150 (IQR 124-165) and higher motor severity than those without T2DM (MDS-UPDRS III 49 vs 28), without significant differences in other scales. We found no difference in CVR impairment between both groups. (Table 1)
Conclusion: We found no association between T2DM and CVR impairment in patients with PD. Further, larger studies are required to elucidate the interplay between T2DM and CVR.
Comparison between groups
To cite this abstract in AMA style:
A. Martínez-Rodríguez, M. Cansino-Torres, D. Ortiz-Zacarias, S. Castillo-Torres, F. Góngora-Rivera, B. Chávez-Luévanos, I. Estrada-Bellmann. Cerebral vasoreactivity in patients with Parkinson’s disease and Diabetes Mellitus [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/cerebral-vasoreactivity-in-patients-with-parkinsons-disease-and-diabetes-mellitus/. Accessed June 15, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/cerebral-vasoreactivity-in-patients-with-parkinsons-disease-and-diabetes-mellitus/