Objective: To evaluate the correlation between CISI-PD by examining its association with four widely-validated functional mobility measures in PD: the 5 Times Sit-to-Stand Test (5xSTS), the Timed Up and Go Test (TUG), the Timed Up and Go – Cognitive Test (Cog TUG), and the Turn 360 Test (see Figures).

Background: The Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD) is a brief and efficient clinician-rated tool that provides a global assessment of disease severity. Although it correlates with established measures such as the MDS-UPDRS and health-related quality of life assessments, its correlation against objective functional mobility measures has not been studied.

Method: We conducted a retrospective chart review of 66 individuals with PD (mean age 69.6±7.6 years; 73.3% male) who attended a movement disorders clinic and PD-specialized physiotherapy between September 2021 and January 2026. CISI-PD scores rated by a movement disorder neurologist were extracted from our research database, along with records of 5xSTS, TUG, CogTUG, and Turn 360 independently evaluated by a physiotherapist. Pearson’s correlation coefficients were used to examine associations.

Results: Out of 66 patient records, 5xSTS, TUG, CogTUG, and Turn 360 measurements were available for 63, 63, 43, and 50 patients, respectively. Higher CISI-PD ratings were consistently associated with slower performance on mobility tests. There were moderate-to-strong correlations between CISI-PD total score with 5xSTS (r=0.39, p=0.002), TUG (r=0.38, p=0.002), CogTUG (r=0.49, p <0.001), and Turn 360 (r=0.50, p <0.001). A combined score of CISI-PD motor and disability items demonstrated even stronger correlations with 5xSTS (r=0.44, p<0.001), TUG (r=0.51, p<0.002), and Turn 360 (r=0.64, p<0.001), but not for CogTUG (r=0.44, p=0.003).

Conclusion: The CISI-PD showed moderate-to-strong correlations with validated functional mobility outcomes in PD. These findings support its use as a practical severity measure that reflects clinically meaningful aspects of mobility impairment.

Figure 1 Five Times Sit-To-Stand Test

Figure 2 The Timed Up and Go Test

The Turn 360 Test

Table 1

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Soke, F., Guclu-Gunduz, A., Ozkan, T. et al. Reliability and validity of the timed 360° turn test in people with Parkinson’s disease. Eur Geriatr Med 11, 417–426 (2020). https://doi.org/10.1007/s41999-019-00285-y

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MDS Abstracts - https://www.mdsabstracts.org/abstract/correlational-study-of-the-clinical-impression-of-severity-index-for-parkinsons-disease-cisi-pd-with-functional-mobility-measures/