Objective: In order to corroborate these findings, we submitted 29 Parkinson’s disease (PD) patients with different stage of disease to an all-night high-density EEG (hd-EEG) study.

Background: Homeostatic adjustments of network excitability occurring during sleep has been proved to be crucial for reducing plasticity thresholds and recent evidence in animal models shown that an impaired synaptic homeostasis (SH) underlies the appearance of levodopa-induced dyskinesia (LID). In order to corroborate these findings, we submitted 29 Parkinson’s disease (PD) patients with different stage of disease to an all-night high-density EEG (hd-EEG) study.

Methods: We performed an hd-EEG (256 channels) in three PD patients groups: (i) de novo (n = 7), (ii) advanced (n = 12); (iii) dyskinetic (n = 10). An age-matched control group was also subjected to the same hd-EEG study (n = 6). Slow wave activity (SWA) with an average spectral density between 0.5 and 4 Hz, was computed for NREM epoch and then normalized by the average SWA across all NREM epochs in the recording time. We compared the average SWA of early (the first five deciles) and late (the last five deciles) NREM sleep.

Results: We found that there was a difference between normal subjects and PD patients in terms of the physiological reduction SWA power, i.e. synaptic strength. Moreover, we also found a difference within the three groups of the same parameter suggesting a not adequate synaptic down-scaling during NREM sleep in patients with dyskinesia.

Conclusions: Our results are consistent with an impaired SH in patients with PD that is more pronounced in those patients with dyskinesia.

XXI World Congress on Parkinson’s disease and Related Disorders Milan, 6-9 December 2015.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/synaptic-homeostasis-in-parkinsons-disease-an-high-density-eeg-study-in-different-stage-of-the-disease/