Category: Parkinsonism, Atypical: MSA
Objective: The aims of this study were to explore the prevalence of and factors associated with camptocormia in a cohort of multiple system atrophy (MSA) patients with different disease durations, and the impact of camptocormia on disability.
Background: It has been reported that camptocormia was common but often under-recognized problem in patients with MSA. there has been considerably less attention given in the literature to the prevalence or related factors of camptocormia in MSA.
Method: The present study enrolled 716 MSA patients were divided into 3 groups according to different disease durations (≤ 3, 3-5, ≥ 5 years). Motor and non-motor symptoms were comprehensively assessed by specific scales. Propensity score matching (PSM) and Cox regression analysis was used to analyze the impact of camptocormia on disability.
Results: The prevalence of camptocormia was 8.9%, 19.7%, 19.2% at the disease duration ≤ 3, 3-5, ≥ 5 years, respectively. The forward binary logistic regression model revealed that older age of onset (OR 1.047, P=0.043), MSA-parkinsonian subtype (MSA-P) (OR 2.037, P=0.042), disease severity (OR 1.060, P<0.001), and low score of frontal assessment battery (FAB) (OR 0.899, P=0.048) were contributors to camptocormia in the disease duration ≤ 3 years group. In the disease duration 3-5 and ≥ 5 years group, the disease severity was the only contributor to camptocormia (OR 1.494, 1.054, respectively, P<0.05). Camptocormia had no significant impact on disability in MSA patients with disease duration <5 years (HR 0.565, P=0.138).
Conclusion: The prevalence of camptocormia increased with the disease duration prolonged. The disease severity was associated with camptocormia at different disease stages. Patients with older age of onset, MSA-P subtype, and low score of FAB were likely to develop camptocormia in the early stage of the disease.
To cite this abstract in AMA style:
L.Y Zhang, B. Cao, QQ. Wei, R.W Ou, H.F Shang. Camptocormia in patients with multiple system atrophy with different disease durations [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/camptocormia-in-patients-with-multiple-system-atrophy-with-different-disease-durations/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/camptocormia-in-patients-with-multiple-system-atrophy-with-different-disease-durations/