Objective: We investigated whether subjective cognitive decline (SCD) can reflect recent cognitive change in patients with Parkinson’s disease (PD) who had shown non-demented cognitive performance in previous neuropsychological assessment.

Background: Preclinical SCD receives growing attentions as pre-mild cognitive impairment (MCI) stage in Alzheimer’s disease, and evidences have been accumulated also in patients with PD. For all assessing tools are consisted with questions comparing current cognitive functioning with past, therefore SCD assessed by questionnaires may relate with past cognitive change.

Methods: We selected patients with PD who had been non-demented on previous neuropsychological test. Subjects were tested cognitive performance again at 2 years after previous assessment, and completed a questionnaire, Cognitive Complaint Interview (CCI). Cognitive change between tests and incidence of cognitive decline were analyzed with CCI score.

Results: A total of 97 cognitively normal (CN) and 63 MCI patients were recruited in the study. CCI score correlated with the changes in the MMSE score and performances of confrontational naming, visuospatial function, visual memory, and executive function. Twenty-eight (28.9%) of CN patients have declined to MCI or dementia, and 16 (25.4%) of MCI patients have converted to dementia. By the logistic regression analysis, CCI score was revealed to be the only factor predicting decline in CN patients, and older age as well as CCI score predicted decline to dementia in MCI patients.

Conclusions: This result demonstrates that SCD is closely associated with objective cognitive deterioration and suggests that SCD can be a biomarker screening cognitive decline in patients with PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/subjective-cognitive-decline-reflects-recent-cognitive-change-in-non-demented-patients-with-parkinsons-disease/