Objective: We investigated the correlation of Neuropsychiatric Inventory(NPI) test score with progression of PD.
Background: PD has characteristic motor symptoms and non-motor symptoms including psychiatric symptoms such as depression,anxiety,psychosis,apathy and night-time behavior disorders.1This conditions may also be more severe and restricting than motor symptoms. NPI asses psychiatrics symptoms which cause a significant burden to individuals with cognitive disorders.2
Method: This prospective study enrolled 50 patients with PD. All participants were examined with UPDRS,NPI,Mini-Mental State Examination,Geriatric Depression Scale.
In our patient group, those with/without dementia findings,those with/without depression,and the duration of the disease (0-4 years, 5-9 years, 10 years or more) and UPDRS score (0-30 points,31-60 points,61 points and above).The correlation of each of these categories with the NPI test score was examined.
Results: The mean NPI test score was found to be 30.35±13.25.
Delusions in 4(8%) patients,hallucinations in 12(24%) patients,agitation in 11(22%) patients,depression in 29(58%) patients,anxiety in 27(54%) patients,euphoria in 3(6%) patients,apathy in 12 (24%) patients,disinhibition in 3(6%) patients,irritability in 8(16%) patients,aberrant motor behaviors in 4(8%) patients,night-time sleep disorders in 33(66%) patients,and appetite changes in 10(20%) patients.
While the NPI was 21.59±9.33 in 38 patients without dementia,it was found to be 29.42±14.53 in 12 patients with dementia(p: 0.001).
The NPI of 21 patients with a disease duration of 0-4 years;It was 13.19±11.17, 17.82±15.57 of 22 patients with 5-9 years of illness,and 15±11.50 for 7 patients with 10 and 10 years above,and no statistically significant difference was found(p: 0.526).
NPI in 21 patients with depression;it was calculated as 21.86±13.48 and 10.86±11.18 in 29 patients without depression(p: 0.003).
NPI in 24 patients with UPDRS score between 0-30; It was found to be 8.08±7.69,13±6.88 in 21 patients between score 31-60;19.20±4.82 in 5 patients with 61 and more,and as the UPDRS value increased,a significant increase was found in the NPI score(p: 0.001).
Conclusion: When the disease disability and duration increased, we found more psychiatric symptoms in patients who had either dementia or depression. As a result, it was emphasized that neuropsychiatric symptoms should be carefully evaluated and identified in the management of PD.
References: 1. Aarsland D, Kramberger MG.Neuropsychiatric Symptoms in Parkinson’s Disease. J Parkinsons Dis. 2015;5(3):659-67. 2. Saari T, Koivisto A, Hintsa T, Hänninen T, Hallikainen I. Psychometric Properties of the Neuropsychiatric Inventory A Review. J Alzheimers Dis. 2020 Aug 26.
To cite this abstract in AMA style:
GG. Uygun, GA. Yuksel, S. Kose. The Neuropsychiatric Inventory:Assessment Of Neuropsychiatric Symptoms In Parkinson’s Disease [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/the-neuropsychiatric-inventoryassessment-of-neuropsychiatric-symptoms-in-parkinsons-disease/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2021
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-neuropsychiatric-inventoryassessment-of-neuropsychiatric-symptoms-in-parkinsons-disease/