Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…Ultra-early Diagnosis of MSA-C Using Biological Biomarkers: A Two-Case Study Employing α-Synuclein PET and Fluid α-Synuclein Seeds Amplification Assay (SAA)
Objective: To report cases in which combined α-synuclein PET and body fluid α-synuclein seeds amplification assay (SAA) enabled biological diagnosis of multiple system atrophy–cerebellar type…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…Modeling Parkinson’s Disease Progression to Quantify Long-Term Treatment Effects via the Concept of ‘Time Saved’
Objective: Evaluate the long-term effectiveness of potential disease-modifying treatments (DMTs) in Parkinson’s disease (PD) using a modelling-based virtual comparator and explore patient-relevant benefits through the…Age-Dependent Peripheral Dissemination of α-Synuclein Seeds: Mechanistic Basis for Blood-Based Early Detection of Parkinson’s Disease
Objective: To evaluate the diagnostic utility of serum α-synuclein (α-Syn) seed amplification assay (SAA) for early PD detection using preformed fibril (PFF)-induced mouse models and…Discordant Siblings Reveal Determinants of Clinical Penetrance in GBA-Associated Parkinson’s Disease
Objective: To investigate clinical, neuropsychological, biomarker, and imaging differences between siblings carrying the same GBA1 variant but discordant for Parkinson’s disease (PD). Background: Variants in…Comprehensive Diagnostic Accuracy of α-Synuclein Seed Amplification Assays Across Non-Parkinsonian Synucleinopathies: A Systematic Review and Diagnostic Meta-analysis
Objective: To evaluate the diagnostic accuracy of αSyn-SAAs across established and prodromal non-Parkinsonian synucleinopathies, including Lewy body disorders (DLB), multiple system atrophy (MSA), isolated REM…TMEM106B Fibrils Potentiate Pathological α-Synuclein Aggregation in Parkinson’s Disease
Objective: To determine whether transmembrane protein 106B (TMEM106B) fibrils promote α-synuclein (α-syn) aggregation and to elucidate the molecular basis of this interaction in Parkinson’s disease…Multi-Omics Analysis Reveals Brain and Biofluid Molecular Changes Induced by Chronic Sleep Fragmentation in a Prodromal Parkinson’s Disease Mouse Model
Objective: To investigate the molecular mechanisms by which chronic sleep fragmentation accelerates the progression of prodromal Parkinson’s disease (PD). Background: Recent epidemiological studies suggest that…Translational evaluation of CSF as a relevant compartment for assessing target engagement of therapeutic anti–α-syn antibodies.
Objective: To evaluate a translational free/total α-synuclein (α-syn) assay framework to quantify in vivo target engagement (TE) of anti–α-syn antibodies in preclinical models and to…
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