A Randomized, Double-blind Phase 3 Trial of Amlenetug Versus Placebo in Patients with MSA: The MASCOT Trial
Objective: Describe the protocol for a randomized, double-blind phase 3 trial evaluating the efficacy and safety of amlenetug versus placebo in slowing clinical progression in…Correlations of catecholamine metabolites and alpha-synuclein by nigral stimulation in Parkinson’s disease model rat
Objective: We aimed to clarify the effects of substantia nigra (SN) stimulation on catecholamine levels and α-synuclein in PD model rats. Background: Catecholaminergic neurons are…Platelets Lipidome as Potential Biomarker of Parkinson’s Disease
Objective: The aim of this proejct is to identify novel biomarkers of Parkinson's disease diagnosis and progression, with a focus on GBA-PD. Background: Our previous…Validation of CSF Alpha-synuclein SAA in an Autopsy Cohort with Systemic Assessment of Lewy Pathology Including the Body
Objective: Based on the recent recommendations by international neuropathologists [1], we attempted to evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) alpha-synuclein (α-syn) seeding amplification…Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy
Objective: In the present study, we aim to counteract regulatory and transcriptional modifiers of autophagy to enhance neuroprotective proteostasis and rescue alpha-synuclein (asyn) toxicity in…ATH434 Slowed Disease Progression in a Phase 2 Study in Multiple System Atrophy
Objective: Evaluate the efficacy and safety of ATH434 treatment in individuals with MSA Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder without…Association Between Heterozygous Loss-of-Function Variants in the MCOLN1 Gene and α-Synucleinopathies
Objective: To evaluate the association between heterozygous loss-of-function variants in the MCOLN1 gene and α-synucleinopathies. Background: Lysosomes play a crucial role in cellular waste disposal,…Alpha-Synuclein Amplification Assays Utilizing Real-Time Quaking-Induced Conversion (RT-QuIC) from Non-Invasive Saliva as a Novel Diagnostic Tool for Patients with Parkinson’s Disease
Objective: The main objective is to evaluate the sensitivity of aSyn-RT-QuIC in diagnosing Parkinson's Disease (PD) from non-invasive saliva. The results will be corroborated in…The relationship between synuclein-related biomarkers and people with upper-respiratory causes of hyposmia or persistent hyposmia
Objective: To determine how smell-testing can enrich screening for individuals with biomarkers related to neuronal alpha-synucleinopathy-related neurodegeneration (NSD). Background: Loss of sense of smell is the…Mass spectrometry-based screening for α-synuclein bioactive marine natural products
Objective: This study identifies marine-derived natural products with binding affinity and aggregation-inhibition activity against α-synuclein (α-syn) using a mass spectrometry (MS)-based screening approach. The objective…
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