Micro- and Nanoplastics in Parkinson’s Disease Pathogenesis An Emerging Environmental Risk Factor
Objective: To synthesize current experimental and translational evidence supporting the hypothesis that micro- and nanoplastics (MNPs) may contribute to Parkinson’s disease (PD) pathogenesis through neuroinflammatory…Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids
Objective: This study aims to determine how patient-specific microglia influence phospho-α‑synuclein aggregation and contribute to disease-relevant phenotypes within human midbrain organoids. Background: Parkinson’s disease (PD)…Novel associations of VPS13C with phenotype and conversion of idiopathic REM sleep behavior disorder
Objective: We aimed to examine the role of VPS13C in the risk of iRBD and its association with α-synucleinopathy. Background: While VPS13C is a recessively…Retrospective Evaluation of microRNA-7-5p and Neuron-Derived α-Synuclein in Prodromal Parkinson’s Disease as Phenoconversion Biomarkers
Objective: To determine if combining microRNA-7-5p (miR-7-5p) and neuron-derived extracellular vesicle (NDEV) α-synuclein (α-syn) would enrich prodromal Parkinson's disease (PD) subjects for those more likely to phenoconvert. Background: Studies have found blood…Novel Modeling Approach for Comparing Treatment-Naive and Post-Treatment Neuronal Synucleinopathy Progression Using Multi-Modal PPMI Data
Objective: To characterize multi-domain progression over the course of Neuronal alpha-Synuclein Disease (NSD), in both treatment-naive and treated individuals. Background: Neuronal alpha-Synuclein Disease (NSD), a…Urine-derived neuronal extracellular vesicle α-synuclein seed amplification assay for synucleinopathies: a non-invasive biomarker study
Objective: To investigate whether pathogenic α-synuclein can be detected using real-time quaking-induced conversion (RT-QuIC) in urine-derived neuronal extracellular vesicles (NEVs) as a fully non-invasive biomarker…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Enteric Alpha-Synuclein Pathology in Early-Onset Parkinson’s Disease and an Incidental Case in Spinocerebellar Ataxia Type 6
Objective: This study aimed to investigate Alpha-synuclein (AS) accumulation in the gastrointestinal (GI) tract of patients with early-onset PD (EOPD). Background: AS accumulation is found…Platelet Lipididomic and Alpha-Synuclein as Peripheral Biomarkers of Disease Progression and Risk in GBA1-Associated Parkinson’s Disease
Objective: To evaluate whether integrated platelet lipidomic and α-synuclein signatures can distinguish idiopathic Parkinson’s disease (iPD), GBA1-associated PD (GBA-PD), and GBA1 non-manifesting carriers (GBA-NMC) from…NIH Multicenter Consortium for Gut-Brain Communication in Parkinson’s Disease: The Master Protocol and Timeline
Objective: To describe the master protocol and timeline for the multicenter Gut-Brain Communication in Parkinson’s Disease Consortium (GBPDC), funded by NIDDK/NIH (UO1) from 2024 to…
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