Session Information
Date: Monday, June 5, 2017
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To investigate the differences of olfactory dysfunction in patients within SWEDDs
Background: The concept of SWEDD(scans without evidence of dopaminergic deficit) originates from the clinical trial literature for Parkinson’s disease (PD). Some debate that SWEDDS contain various disease spectrums (idiopathic PD, essential tremor, dystonic tremor, and other Parkinsonism). There are two reports about olfactory function in patients with SWEDD. Hyposmia occurs in 80-100% of PD cases, and some of SWEDD are similar olfactory dysfunction with PD.
Methods: Parkinson’s disease patients were enrolled at Hanyang University Hospital movement disorders center. This study enrolled 42 patients with SWEDDs (bradykinesia with decremental response (SWEDD-A) = 27, bradykinesia without decremental response (SWEDD-B)=15) , 47 patients with PD and 14 healthy controls. KVSS (Korean version of Sniffin stick test) has been performed on all subjects for evaluation of olfactory function, and parameters including threshold, discrimination and identification were compared among the all groups.
Results: The mean total, threshold, discrimination and identification scores in the PD group were the lowest of the three groups. Smell test scores in the SWEDD group were not significantly difference from that of PD or control. But intermediate scores of smell tests in the SWEDD patients is defined between PD and control. Additionally, in subgroup of SWEDD, the mean threshold and total scores in the SWEDD-A were significantly lower than that of control group.
Conclusions: The intermediate status of smell test in the SWEDD patients in our study may have been due to the heterogeneity of the SWEDD patients. In SWEDD group, olfactory dysfunctions of SWEDD-A are more close to the PD group, and SWEDD-B is more close to the control group. In sight of olfactory dysfunction as prodromal nonmotor features of PD, patients with SWEDD-A might be convert to PD more than patients with SWEDD-B, although clinically and dopamine transporter imaging follow up studies will be needed. To conclude, in common with PD, SWEDD with parkinsonian bradykinesia symptoms tended to have olfactory dysfunction, but not in SWEDD without parkinsonian bradykinesia.
To cite this abstract in AMA style:
S.J. Kang, J.Y. Ahn, H.-T. Kim. Olfactory dysfunction in patient of Scans Without Evidence of Dopaminergic Deficit with parkinsonian bradykinesia [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/olfactory-dysfunction-in-patient-of-scans-without-evidence-of-dopaminergic-deficit-with-parkinsonian-bradykinesia/. Accessed May 9, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/olfactory-dysfunction-in-patient-of-scans-without-evidence-of-dopaminergic-deficit-with-parkinsonian-bradykinesia/