Clinical feasibility of a semi-automated Olfactometry System in α-Synucleinopathies
Objective: To evaluate the feasibility, performance, and diagnostic accuracy of a semi-automated olfactometry system (NOS-DX1000) for standardized assessment of olfactory dysfunction in α-synucleinopathies. Background: Olfactory…Optimizing Identification of Hyposmia for Parkinson’s Disease Risk Screening: Results from the Healthy Brain Aging Study
Objective: To evaluate whether questionnaire-based variables can identify individuals with Olfactory Dysfunction (OD), thereby supporting a targeted preselection approach for Parkinson’s Disease (PD) screening. Background:…Deciphering the NLRP3-Driven Olfactory–Brain Axis in Parkinson’s disease: Neuroprotective Role of Betulin
Objective: The present study aimed to elucidate the molecular mechanism underlying bidirectional olfactory–brain dysfunction mediated through NLRP3 inflammasome activation in cellular models of PD and…Identification of Discriminative Odorants for Parkinson’s Disease and Their Clinical Correlates: A Population-Specific Short-Form Approach
Objective: To identify odorants within the UPSIT that effectively distinguish PD patients from healthy controls and to examine their associations with motor and non-motor symptoms.…Affective Symptom Burden in Individuals with Olfactory Dysfunction in the PREDICT-PD Cohort
Objective: To investigate associations between hyposmia (olfactory dysfunction) and affective symptom burden in PREDICT-PD participants. Background: Anxiety, depression, and hyposmia are common non-motor features of…Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial of a Remote Gamified Physical Activity Programme in Adults with Hyposmia
Objective: To evaluate the feasibility, adherence, acceptability, and safety of a long-term, fully remote, gamified physical activity intervention in adults with objectively confirmed hyposmia, and…Prodromal Parkinson’s Disease in Singapore: Motor and Non-Motor Symptom Patterns
Objective: To determine the differences in motor and non-motor symptoms between subjects categorized as Low, Intermediate, or High Risk for future Parkinson’s Disease (PD). Background:…Understanding the Earliest Phases of Parkinson’s disease: An Update on the Prodromal Effort Within the Global Parkinson’s Genetics Program
Objective: To continue recruitment of global ‘at-risk’, early and prodromal Parkinson’s disease (PD) cohorts to the Global Parkinson’s Genetics Program (GP2, http://gp2.org/), support existing cohorts…Olfactory Dysfunction Across Neurodegenerative Disorders: A Prospective Cross-Sectional Comparison of Parkinson’s Disease, Alzheimer’s Disease and Idiopathic REM Sleep Behavior Disorder
Objective: To investigate whether olfactory function as measured by a standardized odor identification (Sniffin’ Stick) test, differs between patients with Parkinson's disease (PD), Alzheimer's disease…Sex Differences in Prodromal Features of Parkinson’s Disease: Evidence from Large Multi-Centre Cohorts
Objective: To explore sex differences in symptoms of prodromal Parkinson’s disease (PD) in large, population-based multi-centre cohorts of healthy individuals, PREDICT-PD and Healthy Brain Ageing…
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