Session Information
Date: Monday, June 5, 2017
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To evaluate possible risk factors for the development of Progressive Supranuclear Palsy (PSP).
Background: Risk factors for the development of neurodegenerative brain disorders are widely investigated. So far, a number of exogenic risk factors in the environment have been described but only little is known about endogenic factors which might have their origins in a very early period of brain development. Possible risk factors which might influence brain development are adverse childhood experiences (ACE). An association between the burdens of ACE and diseases in the adulthood have been demonstrated including psychiatric diseases but also stroke. Furthermore, people are different in terms of their mathematical or language abilities. We know that brain structures differ between the people with different skills. Therefore, it would be interesting to evaluate whether patients might be better in mathematical or language skills.
Methods: We have ask patients with PSP, Corticobasal Degeneration (CBD), Primary Progredient Aphasia (PPA) and Multiple System Atrophy (MSA) to fill out the Adverse Childhood Experiences Score (ACE) score, furthermore, to answer the question whether they are better in mathematics or language and to hand out school notes as well as give information on their former profession to see whether it is connected to mathematical abilities.
Results: So far, we have included 109 patients with PSP, 21 with CBD, 12 with MSA and 3 with PPA. Form the PSP patients 100 (92 %), from CBD 4 (19 %), from MSA 2 and none of the PPA patiens had more mathmatical skills than language. ACE were more often and serious in patiens with PSP as compared to CBD, MSA and PPA.
Conclusions: Risk factors for the deveopment of neurodegeneration might start early, even during brain development and maturation. Therefore, structural diversities but also adverse experiences which influence brain development might have an impact on neurodegeneration together with genetic and environmental risk factors.
To cite this abstract in AMA style:
S. Lorenzl. Are a „mathematical brain“ and early childhood adverse events possible risk factors that contribute to Progressive Supranuclear Palsy? [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/are-a-mathematical-brain-and-early-childhood-adverse-events-possible-risk-factors-that-contribute-to-progressive-supranuclear-palsy/. Accessed May 17, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/are-a-mathematical-brain-and-early-childhood-adverse-events-possible-risk-factors-that-contribute-to-progressive-supranuclear-palsy/