Multi-Modal Profiling of Peripheral and Central Nervous System T Cells Identifies Cytotoxic α-Synuclein-Reactive Immunity in Multiple System Atrophy
Objective: To define α-synuclein-specific peripheral T cell responses in multiple system atrophy (MSA) in comparison with parkinson’s disease (PD) and healthy controls (HC), and to…SCA27B and MSA-C with Positive Alpha-Synuclein Skin Biopsy – Case Report
Objective: To present the first reported case of Spinocerebellar Ataxia 27B (SCA27B) and clinically probable Multiple System Atrophy-Cerebellar subtype (MSA-C) with skin biopsy positive for alpha synuclein. Background: SCA27B is…Oligodendrocyte-Specific α-Synuclein Pathology is Linked to Severe Motor Phenotype in a Novel Mouse Model of Multiple System Atrophy
Objective: We characterized the formation of α-synuclein pathology and development of motor phenotypes in a mouse model of multiple system atrophy overexpressing human SNCA in…18F-FD4 PET Reveals α-Synuclein Deposition and Clinical Correlations in Multiple System Atrophy
Objective: This study aimed to determine the potential of 18F-FD4 PET to serve as an in vivo pathology mapping tool for MSA, providing initial proof-of-concept for its use in…Proteome-Wide Association and Mendelian Randomization Analyses Identify Plasma GUSB as a Potential Biomarker for Multiple System Atrophy
Objective: To identify plasma protein biomarkers associated with MSA and investigate their potential causal relationships using integrative proteomic and genetic approaches. Background: Multiple System Atrophy…Challenges in Diagnosing and Managing Multiple System Atrophy in Low-Resource Settings: Insights from Nepal
Objective: This study aims to explore the diagnostic and therapeutic challenges faced in the management of Multiple System Atrophy (MSA) in low-resource settings, focusing on…Plasma Protein Profiles Reveal Distinct Molecular Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: We aimed to identify distinct plasma proteins in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA) and evaluate their associations with disease…Distinct Peripheral Immune Profiles of Parkinson’s Disease and Multiple System Atrophy
Objective: We aimed to compare peripheral blood mononuclear cell (PBMC) subsets between Parkinson’s disease (PD) and multiple system atrophy (MSA) to identify disease-specific immune signatures…Differential Effect of alpha-Synuclein on Mitochondrial Morphology in PD and MSA
Objective: In this study, we investigated the morphology of mitochondria and localization of alpha-synuclein as driven by alpha-synuclein isolated from PD and MSA brain-derived tissue.…Efficacy and Feasibility of Telemedicine-Based Dietary Intervention vs. Outpatient Supervision for Drug-Resistant Multiple System Atrophy in Postmenopausal Women During COVID-19
Objective: This study aimed to evaluate the feasibility, safety, and patient satisfaction of initiating and following up on MAD via telemedicine using the Telegram app,…
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