Objective: To determine the clinical characteristics of Parkinson’s Disease (PD) patients with probable Rapid eye movement sleep behavior disorder (pRBD) compared to PD patients without pRBD

Background: Rapid eye movement sleep behavior disorder (RBD) is reported varies in PD patient, 40-60%. It is unclear whether there was a different clinical characteristics between PD patients with RBD and without RBD.

Method: We performed cross sectional study. This study included 52 PD patients from neurology clinic of 3 hospitals in Palembang. We collected informations of demographic variables, age onset and duration of PD, grading of PD, cognitive impairment, and nonmotor symptoms (neuropsychiatry, sleep, atuonomic, sensoric, gastrointestinal and other symptoms). This study used RBD Screening Quesionnaire (RBDSQ) to determine pRBD in PD patients, Hoehn and Yahr criteria for grading of PD and Mini Mental State Examination (MMSE) to determine of cognitive impairment. Non motor symptoms and other variables were obtained through medical records and interviews. We devided the patients into two groups PD with pRBD and PD without pRBD. We performed bivariate analysis chi square and multivariate analysis logistic regression.

Results: Most of PD patients were >60 years old, 55,8% were men, age onset was mostly 50 years old (80.8%), 59,6% patients with Hoehn and Yahr criteria stage 3, more than half patients had suffered from PD for more than 5 years and there were 23 patients (44,2%) who diagnosed pRBD in this study [table1]. In bivariate analysis [table2] and [table3], there was a significant association between disease duration (p=0.002), motor complications (p=0.011), hyposmia (p=0.025) and the incidence of pRBD. But after performing multivariate analysis [table4], only motor complications and hyposmia were associated with the incidence of pRBD in PD patients (p=0,042 (OR 6,843; CI 1,070-43,776) and p= 0,035 (OR 7,212; CI 1,148-45,295))

Conclusion: PD patients with pRBD are more likely to have motor complications and nonmotor symptoms of hyposmia than PD patients without pRBD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-characteristics-of-parkinsons-disease-with-probable-rapid-eye-movement-sleep-behavior-disorder/