Factors Influencing Participation in Genetic Testing Among Prodromal and Family History Positive Controls in Parkinson’s Disease Genetic Cohort in Thailand
Objective: To explore knowledge gaps and awareness of PD, belief in genetic determination, concerns, and group-specific factors, for making a decision to participate in a…Probable RBD and Anxiety in Early Parkinson’s Disease Predict Subsequent Functionally Disabling Medication-Refractory Tremor
Objective: Functionally disabling, medication-refractory (FDMR) tremor is a key indication for device-aided therapy in Parkinson's disease (PD), yet baseline predictors remain poorly characterised. Background: PD…Novel associations of VPS13C with phenotype and conversion of idiopathic REM sleep behavior disorder
Objective: We aimed to examine the role of VPS13C in the risk of iRBD and its association with α-synucleinopathy. Background: While VPS13C is a recessively…Integrating Olink Proteomics and Multimodal MRI to Reveal a Multimodal Signature of Parkinson’s Disease with REM Sleep Behavior Disorder
Objective: To define the distinct multimodal biomarker profile of Parkinson’s disease with rapid eye movement sleep behavior disorder (PD-RBD) by integrating clinical data, Olink-based plasma…The influence of probable rapid eye movement sleep behavior disorder on PD-related motor and non-motor symptoms and multiple functional outcomes among Chinese community-dwelling elderly population
Objective: To investigate associations of probable REM sleep behavior disorder (pRBD) with Parkinson's disease (PD)-related symptoms and functional outcomes in Chinese older adults. Background: The…Serum Nutritional Biomarkers Associated with Isolated REM Sleep Behavior Disorder and α-synucleinopathy Phenoconversion
Objective: To investigate the serum nutritional markers in patients with isolated REM sleep behavior disorders (iRBD) and evaluate their associations with the risk of phenoconversion to α-synucleinopathies. Background:…Two-year Outcomes of Rapid Eye Movement Behavior Disorder Following Globus Pallidus Interna Deep Brain Stimulation for Parkinson’s Disease
Objective: This study evaluated two-year outcomes of rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of patients with Parkinson’s disease (PD) who…Biological Predictors of Clinical Domains in Isolated REM Sleep Behavior Disorder with and without Synucleinopathy and Dopamine Dysfunction
Objective: To determine if baseline biomarkers predict baseline and progression of clinical domains in isolated REM sleep behavior disorder (iRBD). Background: iRBD has high conversion…Prodromal Parkinson’s Disease in Singapore: Motor and Non-Motor Symptom Patterns
Objective: To determine the differences in motor and non-motor symptoms between subjects categorized as Low, Intermediate, or High Risk for future Parkinson’s Disease (PD). Background:…Smartwach Actigraphy for Detection of REM Sleep Behavior Disorder: The dBM-DEV Study
Objective: To evaluate feasibility and performance of multi-night at-home recordings using a smartwatch to (1) detect REM sleep behavior disorder (RBD) compared with polysomnography (PSG)…
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