Category: Parkinson's Disease: Cognitive functions
Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and Parkinson’s disease with cognitive impairment and dementia in a large multi-country cohort in Latin America.
Background: Limited knowledge exists regarding the association between parkinsonism or PD and cognitive impairment and dementia in Latin America.
Method: The 10/66 is a prospective, observational cohort study. The baseline phase data was collected between 2003 and 2007 and the incidence phase data between 2007 and 2011.This population-based cohort study was based in six Latin American countries: Cuba, Dominican Republic, Puerto Rico, Venezuela, Mexico, and Peru. The study comprises 12,865 participants from six countries, including all residents aged >=65 years and residing in urban and rural areas. Cognitive impairment was the main outcome measure for cross-sectional analysis was and dementia to measure the prospective association.Logistic regression models were used to explore the association between parkinsonism/PD with CI. Individual country analyses were combined via fixed-effect meta-analysis. For participants who were followed up for 4 years, sub hazards regression models assessed the prospective association between parkinsonism/PD with incident PDD accounting for competing risk of mortality.
Results: At baseline, the overall prevalence of cognitive impairment was 14% (n=1,581) in six countries. The prevalence of parkinsonism and PD in participants with CI was 30% and 26.2%, respectively. Parkinsonism and PD was individually associated with baseline and incident cognitive impairment after accounting for age, sex, and education. The pooled odds ratios from a fixed effect metanalysis were 2.2 (95%Cis 1.9-2.6) for parkinsonism and 1.9 (95%Cis 1.4-2.4). In terms of prospective association from a competence risk model, the pooled sub-hazard ratios for dementia in the fixed effect metanalysis were 1.5 (95%Cis 1.2-1.9) for parkinsonism and 1.5 (95%Cis 1.0-2.2) for PD.
Conclusion: Parkinsonism and PD were cross-sectionally associated with cognitive impairment and prospectively associated with incident dementia in Latin America. Routine screening for cognitive impairment and PDD with validated tools in PD patients may aid earlier detection of those at greater risk of adverse outcomes.
To cite this abstract in AMA style:
N. Khan, M. Arruabarrena, D. Kim, M. Jiang, J. Llibre-Rodriguez, A. Salgado, I. Acosta, A. Sosa, D. Acosta, I. Jimenez-Velasquez, M. Guerra, A. Salas, L. Contreras, H. Hesse, C. Tanner, M. Prina, J. Guerra. Association between Parkinsonism, Parkinson’s Disease and Cognitive Impairment and Incidence of Dementia in People with Parkinsonism and Parkinson’s Disease in Latin America: A 10/66 Dementia Research Group Study [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/association-between-parkinsonism-parkinsons-disease-and-cognitive-impairment-and-incidence-of-dementia-in-people-with-parkinsonism-and-parkinsons-disease-in-latin-america-a-10-66-d/. Accessed May 10, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-between-parkinsonism-parkinsons-disease-and-cognitive-impairment-and-incidence-of-dementia-in-people-with-parkinsonism-and-parkinsons-disease-in-latin-america-a-10-66-d/