Diagnostic Utility of Routine 1.5T Brainstem Planimetry in Parkinsonism: Evidence from a Vietnamese Cohort
Objective: To compare absolute versus ratio brainstem planimetric measures on routine 1.5T MRI and to identify the best-performing metrics for differentiating PSP and MSA in…Parkinsonism Revealing a Late Form of Niemann-Pick Disease About a Case
Objective: Niemann-Pick type B (NPB) is a rare, autosomal dominant hereditary disorder. Clinical presentation is primarily visceral. Neurological manifestations are rare, unlike in other types…Corticobasal Degeneration With Alien Limb Phenomenon and Severe Cognitive Decline: A Levodopa-Resistant Clinical Case
Objective: To describe a clinical case of corticobasal degeneration presenting with alien limb phenomenon, severe cognitive decline, and resistance to high-dose levodopa therapy. Background: Corticobasal…Attention-Enhanced Deep Learning for Midbrain MRI Segmentation in Parkinson’s Disease
Objective: To develop an automated deep learning framework for robust midbrain segmentation in MRI data of Parkinson’s disease patients. Background: Structural alterations in the midbrain…Multimodal Gait Analysis Using Video Pose Estimation Deep Learning and Walkway Parameters: Parkinsonism Detection and Phenotyping
Objective: To develop a multimodal framework fusing frontal-view video pose estimation frame coordinates with pressure-sensitive walkway features for parkinsonism detection, and to discover clinically meaningful…Midbrain Organoid Modeling and Transcriptomic Characterization of NOTCH2NLC GGC Repeat Expansion–Associated Parkinson’s Disease
Objective: To characterize transcriptomic alterations in patient-derived midbrain organoids carrying NOTCH2NLC GGC repeat expansions and assess their relevance to canonical Parkinson's disease (PD) mechanisms. Background:…Early dopaminergic treatment patterns and 5-year survival in Parkinson’s disease: a nationwide observational study
Objective: To compare the long-term impact of levodopa monotherapy versus early adjunctive therapy combined with levodopa on mortality in PD. Background: Although dopaminergic therapy improves…Determinants of Re-diagnosis of Parkinson’s Disease to Atypical Parkinsonism: Results from the Tracking Parkinson’s Cohort (PRoBAND) and Oxford Parkinson’s Discovery Cohort (OPDC) Cohorts
Objective: We aim to identify the clinical and biomarker features which best predict re-diagnosis to a Parkinson plus syndrome (PPS) in those initially diagnosed with…Baseline Characteristics of Participants Enrolled in a Randomised Pilot Study of Enhanced Tai Chi for Parkinson’s disease
Objective: To describe the baseline characteristics of participants enrolled in a pilot randomised controlled study evaluating Enhanced Tai Chi for Parkinson’s disease (NCT07297368). Background: Exercise-based…Detection of heterozygous ATP7B variants in Hawaii’s Parkinson’s Disease cohort: A case series of six patients
Objective: To describe clinical and demographic features of Parkinson’s Disease (PD) patients, found to be carriers of heterozygous pathogenic/likely pathogenic ATP7B variants. Background: Biallelic ATP7B…
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