Category: Parkinson's Disease: Non-Motor Symptoms
Objective: This study aimed to determine the frequency and factors associated to nocturnal hypertension.
Background: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor signs, including nocturnal arterial hypertension (NAH), a cardiovascular disorder that remains largely underreported in the Africa.
Method: We conducted a 7-month cross-sectional analytical study in the neurology departments of the city of Douala. We included PD patients, and a gender-matched comparison population (1 PD patient for 2 comparison subjects). Disease progression and severity were assessed using the MDS-UPDRS and the Hoehn and Yahr scales respectively. NAH was investigated using a 24h-ambulatory blood pressure measurement. Statistical analysis was performed with SPSS 26.0 software, and predictive factors were identified by binary logistic regression.
Results: We recruited 87 patients including 29 PD and 58 comparison participants (CP). The mean age of PD patients was 64.7 ± 8.4 years, and the mean age at PD diagnosis was 59.4±7.9 years. 65.6% of PD patients were male. In addition, 75.9% had a disease duration of 10 years, and 58.6% were in the advanced stage of the disease according to the Hoehn and Yahr scale with a median stage of 3. Furthermore, 82.8 % were on Levodopa with an average daily dose of 356.1±166.5 mg/day and 39.3% had moderate compliance according to the MARS-5 scale. The frequency of nocturnal hypertension was 58.6% and 48.3% had “non-dipping”. Advanced Hoehn and Yahr stage and moderate MDS-UPDRS I were associated with nocturnal hypertension. Age at diagnosis of PD > 60 years was predictive of nocturnal hypertension, which should be systematically investigated in Parkinson’s disease patients over 60.
Conclusion: Three patients out of five had nocturnal hypertension and the advanced stage of PD was predictive of the occurrence of nocturnal hypertension. Further studies need to be done to provide additional information about this condition.
To cite this abstract in AMA style:
D. Gams Massi, J. Ndjock, A. Magnerou, Y. Mapoure Njankouo. Determinants of nocturnal arterial hypertension in Parkinson’s disease patients in Cameroon [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/determinants-of-nocturnal-arterial-hypertension-in-parkinsons-disease-patients-in-cameroon/. Accessed June 15, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/determinants-of-nocturnal-arterial-hypertension-in-parkinsons-disease-patients-in-cameroon/