Objective: To study the effects of Mucuna Pruriens when administered via inhalation route,  to alleviated symptoms of Parkinson’s disease most importantly freezing of gait.

Background: Mucuna pruriens has been used in Parkinson’s disease as an alternative form of therapy. It has a long history of being in used in multiple cultures and countries.

There has been no work on standardization of Mucuna pruriens extract, or even using different routes of administration of the therapy other than orally. Thus far no published studies have shown Mucuna pruriens to be effective or as good as standard formulation of Levodopa. Mucuna pruriens has previously been reported to used in the form of herbal cigarettes (i.e. smoking) for therapy of Parkinson’s disease

Method: Based on this, we decided to develop a mister to deliver Mucuna pruriens intranasally, since intranasal formulations work faster and better absorbed than oral.

The device (Image.1) was designed to deliver an aerosol without heating the liquid content, to be inhaled by the patients (Image. 2). The formulation of liquid Mucuna extract was equivalent to approximately 33mg/ml of levodopa, and each patient was given 4-5ml of liquid in each session. We used the mister on 2 patients (table.1). Both patients were assessed (Gait, tremor, FOG, etc) by, patients themselves, primary caregiver, 1 neurologist and 1 blinded physician.

Results: Found not to be effective in treating FOG

Conclusion: To answer the initial question, no we do not have a solution… Yet, but this modality of administration should be explored further as the pharmacokinetics is promising. Furthermore, we encourage more work on this particular

Table.1

Image.1

Image.2

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MDS Abstracts - https://www.mdsabstracts.org/abstract/mucuna-pruriens-for-fog-in-parkinsons-disease-do-we-have-a-solution-for-this-trivial-problem/