Objective: To analyze the association between serum levels of low-density lipoprotein (LDL), triglycerides, and interleukin-6 (IL-6) with non-motor symptoms in patients with Parkinson’s disease.
Background: Parkinson’s disease (PD) is characterized not only by motor symptoms but also by a wide range of non-motor manifestations, including sleep disturbances. Neuroinflammatory processes and alterations in lipid metabolism have been proposed to contribute to PD pathophysiology. Biomarkers such as IL-6, LDL, and triglycerides may therefore be associated with the severity of non-motor symptoms in PD.
Method: This cross-sectional study involving 8 patients diagnosed with PD. Serum levels of IL-6, LDL, and triglycerides were measured. Non-motor symptoms and sleep quality were assessed using the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS Part I) and the Pittsburgh Sleep Quality Index (PSQI). Spearman correlation analysis was performed to evaluate associations between biomarkers and clinical measures.
Results: Spearman correlation analysis demonstrated a strong positive correlation between triglyceride levels and the severity of non-motor symptoms measured by MDS-UPDRS Part I (ρ = 0.795, p = 0.018). LDL levels showed a strong positive correlation with triglyceride levels (ρ = 0.881, p = 0.004). IL-6 demonstrated a moderate positive correlation with non-motor symptoms (ρ = 0.691), although the association did not reach statistical significance (p = 0.058). No significant correlations were identified between lipid profile parameters or IL-6 levels and sleep quality assessed by PSQI.
Conclusion: Triglyceride levels were significantly associated with non-motor symptom severity in PD. IL-6 showed a moderate but non-significant association with non-motor symptoms. No relationship was observed between biomarkers and sleep quality.
To cite this abstract in AMA style:
F. de Amor, S. Suryadi, E. Pasmanasari, A. Wati. Association of Triglycerides, LDL, and IL-6 with Non-Motor Symptoms in Parkinson’s Disease: A Cross-Sectional Study [abstract]. Mov Disord. 2026; 41 (suppl 1). https://www.mdsabstracts.org/abstract/association-of-triglycerides-ldl-and-il-6-with-non-motor-symptoms-in-parkinsons-disease-a-cross-sectional-study/. Accessed October 1, 2026.« Back to 2026 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-triglycerides-ldl-and-il-6-with-non-motor-symptoms-in-parkinsons-disease-a-cross-sectional-study/