Objective: To identify the neurobehavioral profile and cognitive phenotype in patients with Idiopathic Parkinson’s Disease without Dementia (IPDWD).

Background: Depression is one of the most common comorbidities in IPDWD. characterized by low self-esteem, low frustration tolerance, feelings of worthlessness and irrational ideas or cognitive distortions; it affects quality of life, the cognitive phenotype, and basic, instrumental, and advanced activities of daily living.

Method: Thirty patients diagnosed with IPDWD in Hoenh and Yahr stages I and II were studied. The mean age was 62.74 years (SD = 8.563). To assess the neurobehavioral profile, the Beck Depression Inventory (BDI) was administered, and for the cognitive phenotype, the Scale for Outcomes in Parkinson’s Disease: Cognition (Scopa-Cog) was used.

Results: A statistically significant relationship was found between the total Scopa–Cog score and the BDI score (Rho = -0.134; p = 0.011). Significant differences were also found in the memory (Rho = -0.236; p = 0.001), attention (Rho = -0.434; p = 0.016), and executive functions (Rho = -0.564; p = 0.001) subscales.

Conclusion: The research results indicate that the neurobehavioral profile of patients, particularly depressive symptoms, is related to the cognitive phenotype at a general level, and in areas such as immediate memory, sustained attention, and the inability to organize, plan, and control their immediate behavior (executive functions).

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-relationship-between-neurobehavioral-profile-and-cognitive-phenotype-in-patients-with-idiopathic-parkinsons-disease-without-dementia/