Objective: This study evaluates the diagnostic yield of an algorithm-based approach implemented in the Parkinson’s Research and Integrated Support Model (PRISM) clinic [1].
Background: Gastrointestinal (GI) dysfunction is highly prevalent in Parkinson’s disease (PD) and contributes significantly to morbidity and reduced quality of life. Accurate diagnosis requires objective testing due to overlapping symptoms and underreporting.
Method: We conducted a retrospective review of 110 adults with PD and GI symptoms evaluated between August 2021 and July 2025. Patients were included if they completed at least one diagnostic study. Testing followed structured algorithms for dyssynergia, dysphagia, and gastroparesis (Figures 1 – 3). Frequencies and abnormal result rates were analyzed.
Results: Among the 110 patients (mean age 71 ± 7.2 years), 98% presented with constipation, 76% oropharyngeal dysphagia, 73% esophageal dysphagia, and 46% gastroparesis (Table 1). Abdominal X-rays were performed in all constipation patients (87% abnormal), anorectal manometry in 52 (84.6% abnormal), and hydrogen breath tests in 31 (67.7% abnormal). Dyssynergic defecation was confirmed only when Rome IV criteria were met. All patients with oropharyngeal dysphagia underwent videofluoroscopic swallow study (83.3% abnormal); 75% had esophagrams (46% abnormal). In esophageal dysphagia, 100% had esophagogastroduodenoscopy (60% abnormal), and 52.5% underwent manometry (69% abnormal). All patients with gastroparesis underwent gastric emptying studies, with 80.4% abnormal.
Conclusion: Algorithm-driven evaluation of GI symptoms in PD yields a high rate of diagnostic findings and supports symptom-specific management. This structured approach streamlines testing and provides a replicable model for personalized care in PD.
Figure 1
Figure 2
Figure 3
Table 1
References: 1. Hey G, Amaris M, Beke M, et al. The fixel GI Parkinson’s research and integrated support model (PRISM). J Parkinsons Dis. 2025;15(3):573-584. doi:10.1177/1877718X251335047
To cite this abstract in AMA style:
G. Hey, M. Beke, N. Walker-Pizarro, C. Rogers, A. Ramirez-Zamora, M. Amaris. Diagnostic Test Utilization and Timing in a Multidisciplinary Gastrointestinal Symptom Clinic: Insights from the Parkinson’s Research and Integrated Support Model (PRISM) Clinic [abstract]. Mov Disord. 2026; 41 (suppl 1). https://www.mdsabstracts.org/abstract/diagnostic-test-utilization-and-timing-in-a-multidisciplinary-gastrointestinal-symptom-clinic-insights-from-the-parkinsons-research-and-integrated-support-model-prism-clinic/. Accessed October 1, 2026.« Back to 2026 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/diagnostic-test-utilization-and-timing-in-a-multidisciplinary-gastrointestinal-symptom-clinic-insights-from-the-parkinsons-research-and-integrated-support-model-prism-clinic/