Objective: To evaluate the clinical characteristics and progression of Parkinson’s disease (PD) in patients with Asian-related LRRK2 variants, G2385R, R1628P and S1647T.

Methods: A total of 202 patients with PD, including 133 risk variant carriers and 69 non-carriers, were followed up. They were evaluated using Modified Hoehn and Yahr (H&Y) staging scale, Unified Parkinson’s disease Rating Scale (UPDRS) part III, Non-Motor Symptom Scale (NMSS), Parkinson’s disease Questionnaire-39 item version (PDQ-39) and Elderly Cognitive Assessment Questionnaire (ECAQ). Means of generalized estimating equation (GEE) model were performed to compare the differences from baseline between LRRK2 risk variant carriers and non-carriers.

Results: At baseline, patients with risk variants were noticed to have significant worse ECAQ score (P=0.0202), PDQ-39 domain 1 (mobility) (P=0.0253) and domain 2 (activities of daily living) score (P=0.0154) than control patients. Based on the Modified H&Y staging scale, our longitudinal analysis showed that the risk variant carriers suffered greater progression than non-carriers after 3 years of follow-up (P=0.041).

Conclusions: Risk variants (G2385R, R1628P and S1647T) in LRRK2 are associated with greater motor severity of disease but not non motor symptoms in PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/longitudinal-evaluation-of-motor-and-non-motor-symptoms-among-lrrk2-risk-variants/