Objective: We investigated the relationship between proteinuria and cognitive dysfunction in patients with Parkinson’s disease.

Background: Impaired renal function and proteinuria have been associated with cognitive impairment and dementia. Chronic kidney disease is considered to be an independent risk factor for Parkinson’s disease. However, few studies have mentioned an association between proteinuria and cognition in Parkinson’s disease.

Methods: Among 172 patients with Parkinson’s disease, 53 had normal cognition, 76 had mild cognitive impairment, and 43 had dementia based on comprehensive neuropsychological tests. The urine protein/creatinine ratio was calculated using the spot urine test.

Results: The urine protein/creatinine ratio was significantly higher in patients with dementia than in those with mild cognitive impairment or cognitively normal patients. Each abnormal neuropsychological test result was associated with increased urine protein/creatinine ratio, except for those associated with the language and calculation domains. After controlling for age, diabetes mellitus, hypertension, symptom duration, and Parkinsonian motor severity, the urine protein/creatinine ratio was significantly associated with decreased cognition.

Conclusions: The urine protein/creatinine ratio was associated with dementia in Parkinson’s disease. These finding suggests that increased protein excretion is associated with cognitive dysfunction in patients with Parkinson’s disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/association-between-urine-proteincreatinine-ratio-and-cognitive-dysfunction-in-parkinsons-disease/