Objective: The aim of this study was to investigate the effect of GRIN2B gene rs1806201 and rs7301328 polymorphisms on the development of Impulse Control Disorder (ICD) in patients with Parkinson’s disease (PD).

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that results from the death of dopaminergic neurons in the substantia nigra (SN) pars compacta. Impulse Control Disorder (ICD) and related behaviors are characterized by an inability to resist the urge to perform a self-rewarding action that will cause long-term harm not all treated PD patients develop ICD, suggesting that there may be a genetic predisposition in genes involved in specific neurotransmitter pathways. Several genetic factors have previously been identified as potential contributors to the development of ICD in Parkinson’s patients.

Method: In our study, we performed DNA isolation on blood samples taken from 137 Parkinson’s patients (69 with and 68 without ICD) and 50 control individuals to investigate the relationship of GRIN2B gene polymorphisms with the development of PD and ICD in Parkinson’s disease. These two polymorphisms were studied using TaqMan SNP and RFLP methods.

Results: No statistically significant difference was found between patients and controls regarding genotype and allele frequency distribution (p>0.05). As a result of the statistical analysis also performed on ICD+ and ICD-cases, a statistically significant difference was not observed (p>0.05). But a significant difference was found in the gender (male) distribution in ICD subgroups within the patient group (p=0.005).

Conclusion: As a result of our study, it was determined that the GRIN2B gene variants rs7301328 and rs1806201 did not have any effect on the development of PD and ICD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-impulse-control-disorder-with-grin2b-gene-polymorphisims-in-parkinson-disease/