Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: The authors performed a retrospective analysis about effects and side-effects for a series of 136 Chinese patients with Wilson disease, treated by Unithiol (DMPS) intravenous infusion, at the University Hospital, Affiliated to Shanghai Jiaotong University School of Medicine.
Background: In Europe and America, therapy drugs approved for treating the patients with Wilson disease (WD) mainly include penicillamine and trientine. But in China, trientine is not available for its price is so especially high to the patients. The WD patients with penicillamine allergy or intolerance are recommended to have orally dimercaptosuccinic acid (DMSA) in mainland China safer and cheaper. The main WD specialists in China give Unithiol (DMPS) intravenous infusion for a few of weeks. The authors observed that data about effects of DMPS infusion on blood routine (WBC,N,Hb,Plt) and liver function(ALT,AST,GGT,Alb) is insufficient. We aimed at finding the effects with data from a single center at the University Hospital Shanghai.
Methods: All of these 136 patients had blood routine (WBC,N,Hb,Plt) before and after DMPS, and along with liver function(ALT,AST,GGT,Alb) before and after the DMPS infusion. We did analysis with SPSS 20.0.
Results: 1.The blood routine(WBC,N,Hb,Plt) had no significant change before and after DMPS treatment(P>0.05); 2.The liver function(ALT,AST,GGT,Alb) had no significant change before and after DMPS treatment(P>0.05); 3. The Urine copper contents increased by 5.5 times.
Conclusions: The DMPS infusion therapy has on effect on WD patients’ blood routine (WBC,N,Hb,Plt) and liver function(ALT,AST,GGT,Alb). Generally, DMPS is a kind of safe and benificial treatment for these series of WD patients. However rare serious side effects had been reported.
To cite this abstract in AMA style:X.P. Wang. Chinese patients with Wilson disease and the treatments: exampled with Unithiol (DMPS) intravenous infusion [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/chinese-patients-with-wilson-disease-and-the-treatments-exampled-with-unithiol-dmps-intravenous-infusion/. Accessed December 1, 2023.
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