Objective: Our primary aim was to study of the clinical characteristics of DD in patients with AD and PD.

Background: The problem of a combination of depression and dementia, in particular due to Alzheimer’s disease (AD) and Parkinson’s disease (PD), has attracted the attention of specialists in the field of neurology. Study of depressive disorders (DD) is great interest depressive disorder, both in terms of influence on the development of dementia, depression, and in the aspect of interaction between the depression and over the neurodegenerative process.

Methods: Examined 44 patients with PD (mean age 67,2±2,4 years) and 38 patients with AD (mean age 69,3±2,6 years). The main methods of investigation were Mini Mental State Examination (MMSE) and Hamilton Psychiatry Rating Scale for Depression (HDRS-17).

Results: The study is shown data on the MMSE – 15,8±2,3 in AD and 23,1±2,6 in PD. The most commonly in patients with AD met anxiety depression (7,9%), apathetic depression (36,8%), and depression with delusions (10.6%),hypochondriacal depression (26,3%) and the dreary depression (18,4 %). In assessing the scale of the Hamilton found 9,2±1,4 at AD. The most commonly in patients with PD met anxiety depression (31,8%), apathetic depression (29,5%), and depression with delusions (18,2%),hypochondriacal depression (11,4%) and the dreary depression (9,1 %). In assessing the scale of the Hamilton found 20,8±1,1 in PD.

Conclusions: Patients with presenile AD were more characteristic of apathetic melancholy and depression, and patients with senile type AD – hypochondriacal depression and depression with delusions. The most pronounced rates of depression were observed in the group with PD. All patients with PD had a depressive disorder, mostly apathetic and hypochondriacal depression.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/depressive-disorders-in-parkinsons-disease-and-alzheimers-disease/