Objective: To evaluate the effectiveness and safety of a supervised live-streaming home-based tele-exercise program in patients with Parkinson’s disease (PD).

Background: Exercise is an important non-pharmacological intervention for Parkinson’s disease (PD), but access to supervised programs is limited. This study evaluated the effectiveness and safety of a live-streaming tele-exercise program in patients with PD.

Method: This multicenter, single-blind, controlled trial compared a 12-week, remotely supervised, home-based, live-streaming, anaerobic tele-exercise program with self-guided exercise using a standardized booklet in patients with PD (Hoehn and Yahr stages I–III). Changes in motor and non-motor scales, cognition, and quality of life post-intervention were compared between the intervention and control group. Exploratory analyses were conducted to examine associations between attendance and clinical outcomes. Safety was monitored throughout the study.

Results: Of the 90 participants enrolled, data from 71 (intervention: N = 27; control: N = 44) who attended ≥50% of the program were included in the final analysis. The intervention group showed greater improvement in Movement Disorder Society–Unified Parkinson’s Disease Rating Scale, Part III scores compared with the control group (p = 0.033), especially rigidity (p = 0.016). Improvements in sleep and fatigue were greater in the intervention group (p = 0.017). Higher attendance was associated with greater motor improvement (r = – 0.405, p = 0.018). No exercise-related adverse events were reported for both groups.

Conclusion: Supervised live-streaming home-based tele-exercise is a safe and effective non-pharmacological intervention that may improve motor and non-motor symptoms in patients with PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/effect-of-a-live-streaming-tele-exercise-in-parkinsons-disease-a-multicenter-controlled-trial-in-south-korea/