Category: Neuroimaging (Non-PD)
Objective: To describe the quantitative magnetic susceptibility(QSM) in Wilson’s disease (WD) and healthy controls
Background: Quantitative susceptibility mapping (QSM) is a post processing technique that uses high-pass filtered phase images and allows differentiation between paramagnetic and diamagnetic influences on the SWI signal. Previous studies on application of QSM in Wilson’s disease point to its potential as a more tailored imaging modality in patients with Wilson’s disease and asymptomatic individuals.
Method: This study was a prospective study, conducted in the inpatient and outpatient departments of Neurology service of the All India Institute of Medical Sciences, New Delhi. Between June 2021 and December 2022, a total of 23 patients and 9 healthy controls were included. All patients underwent clinical examination, and magnetic resonance imaging followed by analysis for QSM.
Results: The mean ages were 20.30±5.59 and 21±4.36 years respectively across the patient and control groups, with a male predominance. The clinical characteristics of the patients are given in table 1. The most common finding among patients was T2/ FLAIR hyperintensity in the midbrain, seen in 20(86.96%) patients followed by putamen (19(82.61%) patients). Blooming was noted in substantia nigra (14(60.87%) patients), followed by globus pallidus(13(56.52%) patients)[table 2].
The difference between the patient and control group were statistically significant in substantia nigra, red nucleus, globus pallidus, and putamen. Highest sensitivity of 91% was noted at a cut-off of 0.02ppm on both sides for putamen. All the areas had a high specificity [table 3].
Conclusion: QSM demonstrates increased metal deposition in case of patients with WD compared to controls and has potential to be employed in further studies involving those with suspected WD.
To cite this abstract in AMA style:
A. Aliyar, D. Radhakrishnan, A. Garg, A. Srivastava, R. Rajan, A. Pandit, A. Das, A. Agarwal. Exploring Quantitative Susceptibility Mapping in Wilson’s Disease- A Prospective Cohort Study [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/exploring-quantitative-susceptibility-mapping-in-wilsons-disease-a-prospective-cohort-study/. Accessed October 12, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/exploring-quantitative-susceptibility-mapping-in-wilsons-disease-a-prospective-cohort-study/