Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To explore the exteroceptive brainstem reflexes in patients with cervical dystonia.
Background: Dysfunction of the inhibitory components along the motor system has been reported in patients with cervical dystonia (CD). We investigated the brainstem involvement, combining a multimodal reflex study to evaluate the segmental and suprasegmental functions in this condition.
Methods: 14 patients with CD and 14 sex- and age-matched healthy controls (HC) were recruited. The blink reflex (BR) including its recovery cycle (BRRC), trigemino-cervical reflex (TCR), and sternocleidomastoid exteroceptive reflex (SER) were recorded in all subjects. Demographical and clinical features were collected for all patients, including severity, pain, tremor and sensory trick.
Results: The polysinaptic component of the BR is prolonged in patients with CD compared to HC (iR2 32,86 vs 38,06 ms, cR2 33,04 vs 40,23 p < 0.001). BRRC is impaired at 100 ms (0,20 vs 0,40, p = 0.009) and 200 ms (0,27 vs 0,42, p = 0.038) intervals in CD. The P19/N31 component of the TCR is abnormal in all patients (p < 0.001). The SER was present in 31% of patients compared to HC (p < 0.001). Loss of inhibition at BRRC is correlated with history of disease (r = 672, p = 0.008), as well as clinical severity and the polysinaptic component of the BR (r = 0.713, p = 0.004).
Conclusions: We found either segmental than suprasegmental brainstem networks dysfunction in patients with CD. Loss of the suprasegmental inhibitory control is significantly correlated with duration of disease.
To cite this abstract in AMA style:P. Tocco, M.C. Tozzi, S. Monaco, L. Bertolasi. Exploring the brainstem functions in cervical dystonia [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/exploring-the-brainstem-functions-in-cervical-dystonia/. Accessed September 23, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/exploring-the-brainstem-functions-in-cervical-dystonia/