Category: Parkinson's Disease: Genetics
Objective: The aim of our study was to conduct a cohort that demonstrates genetic variations in cytokines genes involved in the physiopathology, the development and the heterogeneity of the clinical course in PD.
Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative condition following Alzheimer’s disease. It is triggered by the immune system in individuals with genetic susceptibility.
Method: We conducted a retrospective analysis of patient’s data diagnosed with PD at the Charles Nicolle Hospital, in the neurology department (2021-2023). Additionally, we included control subjects in our study. In collaboration with the department of immunology, patients and healthy controls underwent investigations for serum levels of IL-1β and IL-6. Our study focused specifically on genetic cytokines polymorphisms in the development of PD.
Results: Our study included 26 PD patients, with a sex-ratio(M/F)=0.57 and an average age=64.08 years, along with 30 control subjects. With respect to genetic study, in disease group, C allele frequency at Il-1βwas=65.9%, T allele frequency at il-1β was=34.10%, C allele frequency at IL-6 was=19%, and G allele frequency at IL-6 was=81%. Genotype distributions at IL-1 was as follows: CC: 42% in PD versus 40.9% in controls, CT: 28.6% in PD versus 40.9% in controls, and TT: 19% in PD versus 18.2% in controls. Genotype distribution at IL-6 was as follows: CC=4.8% in PD versus 0% in controls, CG=28.6% in PD versus 21.4% in controls, and GG genotype=66.7% in PD versus 78.6% in controls. Our study found no association of neither IL-6 nor IL-1β with PD susceptibility in the Tunisian population.
Conclusion: Our inconsistent results are possibly due to various ethnics of the studied populations, and the eventual presence of other single nucleotide polymorphisms in linkage disequilibrium with those investigated in our study.
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To cite this abstract in AMA style:
S. Frikha, O. Ben Othmen, S. Fezai, A. Achouri, M. Ben Mahmoud, S. Fray, H. Jamoussi, M. Fredj, N. Ben Ali. Genetic Study of polymorphism of cytokines in Parkinson’s disease. [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/genetic-study-of-polymorphism-of-cytokines-in-parkinsons-disease/. Accessed October 4, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/genetic-study-of-polymorphism-of-cytokines-in-parkinsons-disease/