Category: Parkinsonism, Others
Objective: To examine the causal link between peripheral immune cell traits and Parkinson’s disease (PD) risk.
Background: Observational studies have highlighted an association between peripheral immune cells and PD, suggesting potential immunological contributions to the disease pathology.
Method: We conducted a two-sample Mendelian randomization (MR) study using GWAS data to assess the link between immune cell traits and PD risk. This involved a rigorous selection of instrumental variables and was complemented by multivariable Mendelian Randomization (MVMR) analysis and validation in the PD age at onset (AAO) database.
Results: We identified four blood immune-cell-related traits that have a causal effect on PD risk. One trait was found to increase PD risk: CD3 on CD45RA+ CD4+ T cells (odds ratio [OR] and 95% confidence interval [CI] = 1.05 (1.04–1.06), P = 4.38E-28). The other three traits were found to decrease PD risk: 1) the percentage of T lymphocytes predominantly expressing CD45RO+ CD4+ CD25+ CD127hi (OR [95% CI] = 0.93 (0.91–0.95), P = 6.19E-11); 2) CD64 on CD14+ CD16– monocyte (OR [95% CI] = 0.85 (0.79–0.92), P = 4.36E-05); 3) CD64 on monocyte (OR [95% CI] = 0.84 (0.78–0.91), P = 2.08E-05). All the above results passed the Bonferroni correction and all sensitivity tests. Furthermore, these findings were also well validated in MVMR analysis and supported in the PD AAO database.
Conclusion: Our study underscores the correlation between peripheral immune cell traits and the risk of PD, providing insights into the relationship between peripheral immunity and PD.
To cite this abstract in AMA style:
JL. Wang, Y. Fang, YL. Li, R. Zheng, Y. Chen, J. Tian, XZ. Yin, JL. Pu, BR. Zhang. Immune cell traits and Parkinson’s disease: A Mendelian randomization study [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/immune-cell-traits-and-parkinsons-disease-a-mendelian-randomization-study/. Accessed October 4, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/immune-cell-traits-and-parkinsons-disease-a-mendelian-randomization-study/