Session Information
Date: Monday, June 20, 2016
Session Title: Quality of life/caregiver burden in movement disorders
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate the association of direct and indirect costs of Parkinson’s disease (PD) and health-related quality of life (HRQoL) in a Mexican population.
Background: Parkinson’s disease is a progressive neurodegenerative disorder for which there is no cure at present. Several studies have established the association of motor and non-motor symptoms to HRQoL. On the other hand, relatively few is known about socioeconomics affecting HRQoL.
Methods: A cross-sectional study was conducted with consecutive Mexican subjects with PD from October 2015 to January 2016 in a movement disorders clinic in Mexico. Direct (medical and non-medical) and indirect costs of the disease were calculated monthly, updated to United States dollar (USD), 2016. HRQoL was assessed using the EQ-5D-5L questionnaire. Additionally, adherence was assessed with Morisky-Green Score.
Results: Forty-seven patients were included. The mean age and disease duration were 61.9 ± 13.1 years and 8.1 ± 6. years, respectively. Twenty-five patients were male (53.2%). Overall monthly costs accounted for 315.1 ± 298.1 USD (108.0 ± 88.4 USD for direct costs and 207.1 ± 299.5 USD for indirect costs). EQ-5D-5Lindex and EQ-VAS score were 0.60 ± 0.20 (range 0.15–1.0) and 72.6 ± 18.4, accordingly. Fifteen patients adhered to pharmacotherapy (31.9%). A statistically significant negative correlation coefficient was observed between EQ-5D-5Lindex and indirect costs (r= -0.46, p≤0.001). When ability to self-care was analyzed, a significant increase of 260 USD/month in indirect costs was observed from mild to moderate levels (77.9 ± 143.9 USD and 337.2 ± 473.3 USD, p=0.049; respectively). No significant differences were observed in HRQoL for direct costs. Patients that required home assistance have a four-fold increase in monthly total costs (148.0 ± 142.6 USD versus 610.0 ± 271.9 USD, p≤0.001) and a 30% decrease in EQ-5D-5Lindex (0.68 ± 0.16 versus 0.47 ± 0.21, p=0.003). No difference in costs was observed in adherent versus non-adherent patients. However, adherent patients scored 13 points more in EQ-VAS versus non-adherent (81.5 ± 19.7 and 68.4 ± 16.4, p=0.018; respectively).
Conclusions: Higher indirect costs are related to lower HRQoL scores and account for up to two thirds of monthly costs. Current self-rated health statuses were better in adherent patients.
To cite this abstract in AMA style:
M. Rodríguez-Violante, A. Jorge de Saráchaga, A. Cervantes-Arriaga, H. Soto-Molina, M. Márquez-Cruz. Implications of direct and indirect costs in health-related quality of life in Parkinson’s disease: A cross-sectional study in Mexico [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/implications-of-direct-and-indirect-costs-in-health-related-quality-of-life-in-parkinsons-disease-a-cross-sectional-study-in-mexico/. Accessed November 10, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/implications-of-direct-and-indirect-costs-in-health-related-quality-of-life-in-parkinsons-disease-a-cross-sectional-study-in-mexico/