Category: Parkinson’s Disease: Clinical Trials
Objective: The objectives of this study are to describe the prevalence of different motor phenotypes (MP) in a cohort of Parkinson’s Disease (PD) patients, to evaluate how MP change over time and to identify factors associated with a shift to Postural Instability and Gait difficulties (PIGD) phenotype.
Background: PD is a heterogeneous disease and different clinical motor phenotypes have been described to gain a better understanding of the disease. The PIGD subtype has been associated with clinical progression and response to treatment.
Method: The data was obtained from a baseline evaluation (V0) and a 5-year follow-up (V5±3 months) visit of PD patients included in the COPPADIS-2015 Study (an observational, descriptive, 5-year follow-up, national [Spain], multicenter study). MP was calculated on both visits based on Jankovic classification in TD (tremor dominant), ID (indeterminate) or PIGD (postural instability and gait difficulty). Sociodemographic and PD-related variables were collected.
Results: At V0, 687 PD patients (62.8 ± 9 years old, 59.8% males) were included in the analysis. TD was the most frequent phenotype (45%), followed by PIGD (39.4%) and ID (15.6%). At V5, MP was evaluated in 429 PD patients (62.61 ± 8.90 years old, 57.11% males). Out of these, 192 patients (44.76%) were PIGD, 147 (34.27%) TD and 90 patients (20.98%) were ID phenotype. A higher prevalence of cognitive impairment, higher PDQ39 score and NMS score at V5 were found in ID and PIGD phenotypes.
Up to 46.15% of the patients presented a change in phenotype from V0 to V5. The most frequent change was to the PIGD phenotype (48.99). A longer disease duration, higher levodopa-equivalent daily dose and more freezing of gait at baseline visit were associated with the shift from other phenotypes to PIGD. At V5, a higher NMS and PDQ39 score was found in patients who shifted to PIGD versus patients who did not. No association was found in NMS nor PDQ39 score between patients who presented a change in MP to PIGD at V5 versus stable PIGD phenotype from V0 to V5.
Conclusion: Up to 46.15% of the patients presented a change in their phenotype from V0 to V5. PIGD was the most frequent phenotype at V5. A longer disease duration, higher levodopa-equivalent daily dose and more freezing of gait at baseline visit were related with changing from other phenotypes to PIGD. Higher NMS and PDQ39 scores at V5 were found in patients who shifted to the PIGD phenotype.
To cite this abstract in AMA style:
MF. Valero García, E. Bargay Pizarro, I. Legarda Ramirez, B. Vives Pastor, L. Núñez Santos, S. Jesus Maestre, M. Cosgaya, J. Garcia Caldentey, N. Caballol, J. Hernández Vara, I. Cabo, L. López Manzanares, I. González Aramburu, C. Borrué, B. Solano Vila, M. álvarez Saúco, L. Vela, S. Escalante, E. Cubo, JC. Martínez Castrillo, P. Sánchez Alonso, MG. Alonso Losada, N. López Ariztegui, I. Gastón, J. Kulisevsky, M. Seijo Martinez, C. Ordás, P. Martinez-Martin, P. Mir, D. Santos-García. Motor Phenotype Changes over time in Parkinson’s Disease. A 5-year Follow-up Study [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/motor-phenotype-changes-over-time-in-parkinsons-disease-a-5-year-follow-up-study/. Accessed October 12, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/motor-phenotype-changes-over-time-in-parkinsons-disease-a-5-year-follow-up-study/