Category: Ataxia
Objective: Describe the first Brazilian case of opsoclonus due to COVID-19 infection
Background: Opsoclonus-myoclonus is a rare movement disorder associated with a variety of conditions, like tumours, viral and bacterial infections, and other clinical situations; Recently, that have been reported by some authors, appearing several days after the beginning of COVID-19 infection.
Method: A 39-year-old male patient was admitted due to diplopia and blurred vision, associated with loss of balance. Neurological examination disclosed opsoclonus, mild limb and truncal ataxia and facial myokymia.
Results: An extensive laboratory and radiologic evaluation were normal. The patient improved completely after methylprednisolone pulse therapy for 5 days. As for 30 days after discharge, there were no more neurological abnormalities.
Conclusion: This is the first Brazilian patient presenting with opsoclonus secondary to COVID-19 infection. Opsoclonus is a rare syndrome and may occur after many different conditions. SARS-CoV-2 infection must be included among them, and normal brain magnetic resonance imaging and spinal fluid examination do not rule out this diagnosis.
References: 1. Sahu JK, Prasad K. The opsoclonus-myoclonus syndrome. Pract Neurol, 2011; 11: 160 – 6
2. Ellul MA, Benjamin L, Singh B et al. Neurological associations of COVID-19. The Lancet Neurol, 2020; 19: 767 – 83
3. Shah PB, Desai SD. Opsoclonus myoclonus ataxia syndrome in the setting of COVID-19 infection. Neurology, 2021; 96 (1)
4. Emamikhah M, Babadi M, Mehrabani M et al. Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature. J Neurovirol, 2021; 25: 1 – 9
5. Foucard C, San-Gill A, Tarrano C et al. Acute cerebellar ataxia and myoclonus with or without opsoclonus: a parainfectious syndrome associated with COVID-19. Eur J Neurol, 2021. DOI: 10.1111/ene.14726
6. Taquet M, Geddes JR, Husain M et al. 6-month neurological and psychiatric outcomes in 236379 survivors of COVID-19: a retrospective cohort study using electronic health records. The Lancet, 2021. DOI: 10.1016/S2215-0366(21)00084-5
7. Varatharaj A, Thomas N, Ellul MA et al. Neurological and neuropsychiatric complications of COVD-19 in 153 patients: a UK-wide surveillance study. The Lancet Psychiat, 2020; 7: 875 – 882
To cite this abstract in AMA style:
F. Sakeff, A. Vilar. Opsoclonus after Covid-19 infection [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/opsoclonus-after-covid-19-infection/. Accessed October 7, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/opsoclonus-after-covid-19-infection/