Objective: To evaluate the prevalence and clinical structure of non-motor symptoms in patients with Parkinson’s disease in the Uzbek population using the MDS-NMS scale.

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor manifestations. Non-motor symptoms (NMS) significantly affect quality of life, disease progression, and treatment outcomes. Despite increasing recognition of the importance of non-motor manifestations, epidemiological data regarding their prevalence and clinical distribution in Central Asian populations remain limited.

Method: This cross-sectional observational study conducted in  88 patients, 62% male, mean age 68.6 years, mean duration of disease 7.2years, diagnosed with idiopathic Parkinson’s disease according to established clinical criteria. Patients were recruited from neurological departments and outpatient clinics. Demographic data, disease duration, and disease severity according to the Hoehn and Yahr staging scale were recorded. Non-motor symptoms were assessed using the validated MDS-NMS scale, which evaluates multiple domains including sleep disturbances, mood disorders, autonomic dysfunction, gastrointestinal symptoms, and sensory complaints. Descriptive statistics were used to estimate prevalence, and correlations between disease duration and NMS burden were analyzed.

Results: Non-motor symptoms were present in 92.5% of patients. Sleep disturbances were the most common manifestation (68.3%), followed by constipation (61.7%), fatigue (57.5%), and anxiety or depressive symptoms (54.2%). Autonomic dysfunction was observed in 49.2% of patients, while sensory symptoms such as pain were reported in 46.7%. Higher total MDS-NMS scores were significantly associated with longer disease duration and more advanced Hoehn and Yahr stages (p < 0.05).

Conclusion: Non-motor symptoms are highly prevalent among patients with Parkinson’s disease in the Uzbek population.  Routine evaluation using the MDS-NMS scale enables earlier detection and improved clinical management of these manifestations. Incorporating standardized non-motor symptom assessment into routine neurological practice may enhance comprehensive care for patients with Parkinson’s disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-and-profile-of-non-motor-symptoms-in-parkinsons-disease-in-the-uzbek-population-assessed-with-the-mds-nms-scale/