Objective: Assess the psychometric properties of PD-CRS in a Colombian population.

Background: Cognitive impairment is frequent amongst people living with Parkinson’s disease: up to 40% of patients exhibit symptoms of mild cognitive impairment (1) and 26% meet the criteria for dementia (2). PD-CRS (3) is one of the recommended scales by the Movement disorder Task Force (MDS-TF) for level I screening of dementia. However, its psychometric properties have not been studied in the Colombian population.

Method: A cross-sectional study was conducted on 100 patients with Parkinson’s disease diagnosed by a movement disorder neurologist. The patients were evaluated with PD-CRS (3) and MoCA. Principal component analysis was conducted, and then confirmatory factor analysis was implemented through the maximum-likelihood method. Internal consistency was evaluated using Cronbach α. Convergent and divergent validity were also calculated and concurrent validity with the MoCA was assessed.

Results: 62% were males. Their median age was 68 years (IQR 57-74) and median disease duration was 4 years (IQR 2-9). 77% were classified on early stages (Hoehn and Yahr ≤2) while the MDS-UPDRS part III score was 25 (IQR 15,5-38) (table 1). In the principal component factor analysis, the pattern matrix unveiled an amnesic and a non-amnesic domain (figure 1). Confirmatory factor analysis showed similar explanatory capacity (λ≥0.50) for items other than naming (λ=0.34). Cronbach’s α for the full 9-items instrument was 0,744. MoCA and PD-CRS total scores were correlated (ρ=0.713, p=0.000). Assuming a cut-off score of 62 points (as proposed in neighbor populations)(4), there is an agreement of 91% with the definition of dementia by MoCA (k=0,662; p=0,000).

Conclusion: PD-CRS has acceptable psychometric properties for the Colombian population and has significant correlation and agreement with a validated scale (MoCA).

References: 1. Baiano C, Barone P, Trojano L, Santangelo G. Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson’s Disease: A Meta‐Analysis. Mov Disord. 2020 Jan;35(1):45–54.
2. Severiano e Sousa C, Alarcão J, Pavão Martins I, Ferreira JJ. Frequency of dementia in Parkinson’s disease: A systematic review and meta-analysis. J Neurol Sci. 2022 Jan;432:120077.
3. Pagonabarraga J, Kulisevsky J, Llebaria G, García-Sánchez C, Pascual-Sedano B, Gironell A. Parkinson’s disease-cognitive rating scale: A new cognitive scale specific for Parkinson’s disease: Cognitive Rating Scale for PD. Mov Disord. 2008 May 15;23(7):998–1005.
4. Serrano-Dueñas M, Serrano M, Villena D, Granda D. Validation of the Parkinson’s Disease-Cognitive Rating Scale Applying the Movement Disorder Society Task Force Criteria for Dementia Associated with Parkinson’s Disease. Mov Disord Clin Pract. 2017 Jan;4(1):51–7.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/psychometric-properties-and-construct-validity-of-the-parkinsons-disease-cognitive-rating-scale-pd-crs-in-colombia/