Objective: In the present study, we developed a nanozyme (Se@PB-ACPP) incorporating selenium-loaded Prussian blue (PB) and modified it with an activatable cell-penetrating peptide (ACPP) to enable a synergistic therapy targeting both oxidative stress and inflammation in PD.
Background: Parkinson’s disease (PD) is a prevalent neurodegenerative disorder lacking effective drugs for addressing its etiology, largely due to the challenges posed by the blood-brain barrier (BBB) and limited plasma exposure. Selenium (Se) in the form of selenium protein demonstrates potent antioxidant and anti-inflammatory properties that confer neuroprotective effects.
Method: 1. Preparation and characterization of a targeted nanoparticle-based selenium delivery system based on ACPP modifications
2. Efficacy of ACPP-modified targeted nanoparticle-loaded selenium delivery system in MPTP Parkinson’s disease mouse model.
3. Mechanism study of targeted nanoparticle selenium delivery system modified by ACPP for MPTP Parkinson’s disease mouse model.
Results: The Se@PB-ACPP demonstrates a significant enhancement in motor function in a mouse model of PD induced by MPTP. Findings from immunohistochemical (IHC), transmission electron microscopy (TEM), immunoblotting, and Golgi staining indicate that Se@PB-ACPP enhances the quantity of tyrosine hydroxylase (TH) immunopositive cells in the substantia nigra, upregulates TH protein expression levels in both the substantia nigra and striatum, ameliorates neuronal ultrastructural damage in the substantia nigra, and improves dendritic morphology and spine density in dorsolateral striatal neurons. Furthermore, these functions may be achieved by enhancing antioxidant stress levels and inhibiting inflammatory processes.
Conclusion: 1. The Se@PB-ACPP has good biocompatibility, brain targeting, and scavenging of oxygen free radicals, thus improving the bioavailability of selenium.
2. Se@PB-ACPP improved the motor symptoms of MPTP-induced PD mice, alleviated MPTP-induced neurotoxicity, and had a good neuroprotective effect.
3. These effects are believed to be a result of the anti-inflammatory and antioxidant stress properties of Se@PB-ACPP.
4. Se@PB-ACPP, as a targeted nanomaterial, holds promise as a novel therapeutic approach for the treatment of PD.
To cite this abstract in AMA style:
W. Bi, L. Zhu, T. Chen, Y. Cen, J. Zou, Z. Su. Therapeutic Effect and Mechanism of Targeted Nano-selenium in Mouse Model of Parkinson’s Disease Induced by MPTP [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/therapeutic-effect-and-mechanism-of-targeted-nano-selenium-in-mouse-model-of-parkinsons-disease-induced-by-mptp/. Accessed October 22, 2026.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/therapeutic-effect-and-mechanism-of-targeted-nano-selenium-in-mouse-model-of-parkinsons-disease-induced-by-mptp/