A Human Factors Study of the DopaFuse® Delivery System
Objective: SynAgile has developed the DopaFuse Delivery System to noninvasively and continuously administer oral LD/CD into the mouths of patients with PD. The System is…The evaluation of exosomes as a biomarker of Parkinson’s disease
Objective: This study is aimed to investigate whether the number and the contents of serum exosomes can serve as a useful biomarker for the diagnosis…Effects of Virtual Reality Exercise Program using the Sony PlayStation 2 gaming platform on Balance, Emotion and Quality of Life in Patients with Parkinson’s Disease
Objective: This study was to investigate the effectiveness of a 12-week virtual reality(VR) exercise program designed around low-cost VR device, the Sony PlayStation 2 (PS2) gaming…Quantitative study of subthalamic ERG potassium channels in parkinsonian discharges
Objective: This study describes the role of the subthalamic ERG Potassium (ERG K+) ion channel conductance in cellular excitability in subthalamic nucleus (STN) neurons towards…IncobotulinumtoxinA is effective, long lasting and well tolerated treatment of hemifacial spasm
Objective: Hemifacial spasm (HFS) is a common movement disorder characterized by involuntary contractions of the muscles innervated by facial nerve. Background: To evaluate the effect…A single nigral injection of human ENGRAILED-1 induces long-lasting behavior benefit in an experimental primate model of Parkinson Disease
Objective: Evaluate the efficacy of a single nigral injection of human ENGRAILED-1 (hEN1) in a recognized chronic MPTP macaque model. Background: EN1 homeoprotein has been…Preclinical Development of a Novel Carbidopa/Levodopa Precision Olfactory Delivery (POD®) Drug-Device Combination Product for the Treatment of OFF Episodes in Parkinson’s Disease
Objective: This series of preclinical studies of novel levodopa and carbidopa/levodopa powder formulations delivered by the POD device to rats and non-human primates (NHP) guided…Safety of Gocovri in Clinical Practice: One-year Post-launch Pharmacovigilance Data
Objective: To assess the real-world safety profile of Gocovri® (amantadine) extended release capsules one year post-launch. Background: Gocovri received FDA approval in August 2017 for…Successful Treatment of Orthostatic Tremor using Perampanel
Objective: Orthostatic tremor is notoriously difficult to treat. To date, there has only been one case report of marked improvement of symptoms using perampanel. We present…Cockayne Syndrome manifesting as late adult onset cerebellar ataxia: expanding the phenotype
Objective: To report an atypical case of Cockayne Syndrome manifesting as pure adult onset cerebellar ataxia. Background: Cockayne Syndrome (CS) is a rare autosomal recessive…
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