K0706, A Potent Orally Bioavailable Brain-Penetrating Selective Inhibitor of cABL Protein Tyrosine Kinase, Exhibits Neuroprotective Activity in Preclinical Models of Parkinson’s Disease
Objective: Preclinical assessment of K0706, a potent c-Abl inhibitor, as a neuroprotective disease modifying agent for the treatment of Parkinson’s disease (PD) related neurodegeneration using…Effects of levodopa on LTP-like plasticity induced by quadripulse magnetic stimulation in Parkinson’s disease
Objective: To study LTP-like effect induced by QPS on primary motor cortex of PD patients in “on” or “off” medication state and reveal the relationship…Multiple system atrophy with predominant striato-nigral degeneration (MSA-P) and TDP-43 pathology: an unusual pathologic variant of MSA
Objective: To report a patient with MSA with concomitant occurrence of TDP-43-labeled and a-synuclein labeled inclusions in oligodendrocytes. Background: The pathologic hallmark in multiple system atrophy…The effect of baseline cognitive status of Parkinson’s disease on the outcome after deep brain stimulation surgery
Objective: To evaluate the effect of baseline cognitive status of Parkinson’s disease (PD) on the outcome after deep brain stimulation (DBS) surgery. Background: Advanced dementia…Association of Charcot-Marie-Tooth disease, Parkinson’s disease and FIG4 mutations
Objective: Here we report a patient with Charcot-Marie-Tooth (CMT) 4J disease (related to FIG4 mutations) who developed an early-onset Parkinson’s disease during evolution. Background: FIG4 encodes…Neuromelamin-MRI in patients with Pure Autonomic Failure
Objective: To assess the utility of neuromelanin-MRI (NM-MRI) methods in a prodromal alpha-synuclein disorder, Pure Autonomic Failure (PAF). Background: PAF is a peripheral alpha-synucleinopathy (AS)…Nrf2 pathway in patients with Parkinson’s disease
Objective: To demonstrate the activation of Nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in PD patients. Background: Experimental data indicated the critical involvement of Nrf2…Measuring perceived-health status in Parkinson’s Disease – the role of London Handicap Scale
Objective: To characterize the handicap of a broad sample of PD patients. Background: Measuring perceived-health status has an important role in Parkinson’s Disease (PD) to…Harmonics: A reliable marker in tremor analysis for the differential diagnosis of Parkinson’s disease and multiple system atrophy
Objective: We aim to develop a reliable and convenient marker derived from the tremor characteristics to identify the two conditions. Background: The early-stage identification between…Impact of quantitative assessment of parkinsonian symptoms using wearable technology on treatment decisions
Objective: We evaluated the impact on routine treatment decisions of using the Parkinson’s KinetiGraph(PKG) to provide objective patient information Background: Continuous objective measurements using wearable technology may…
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