Identification and characterization of anti-prionic compounds that disassemble αSyn prions as a novel therapeutic approach for synucleinopathies
Objective: Stabilization of monomeric α-synuclein protein (αSyn) by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for synucleinopathies .…Relationship between REM sleep without atonia and sleep architecture in multiple system atrophy
Objective: To investigate whether REM sleep without atonia (RWA) is associated with sleep architecture in patients with multiple system atrophy (MSA). Background: In MSA patients,…Correlations between amantadine usage, gait, and cognition in PSP: a post hoc analysis of the davunetide trial
Objective: Amantadine anecdotally improves gait and balance in PSP, potentially by increasing alertness, but there are no definitive data to support this observation. We investigated…Temporhythmal Correction: The New Way of Therapy and Diagnostic Secondary Vascular Parkinsonism
Objective: It is known that, in vascular parkinsonism (VP) and Parkinson’s disease (PD) it is observed shortening of steps, bradikinesia, oligokinesia, gait disorders and also…May Safinamide have a Role in Atypical Parkinsonism? A Retrospective Study in Clinical Practice
Objective: To evaluate efficacy and safety of safinamide in atypical parkinsonian syndromes. Background: Safinamide (50-100 mg) has proved efficacy as an add-on treatment to levodopa…Mutations of COX20 affect the assembly and function of complex IV causing early onset ataxia, dystonia and neuropathy
Objective: To find the causes of an early onset complex movement disorder in two sisters from a non-consanguineous family, and confirm the COX20 variants responsible for such mitochondrial…Clinical progression of Parkinson’s disease: insights from the NINDS common data elements
Objective: To synchronize data collection, the National Institute of Neurological Disorders and Stroke recommended Common Data Elements (CDEs) for use in Parkinson’s disease (PD) research.…Home validation of a smartphone-based tapping task to assess medication responsiveness in Parkinson’s disease
Objective: To validate a timed tapping task (TTT) on a smartphone to ascertain differences in OFF- and ON-phases in Parkinson’s disease (PD) in the home…The impact of motor and non-motor symptoms on walking capacity in people with Parkinson’ disease
Objective: This study aimed to evaluate the motor and non-motor factors associated with walking capacity in people with Parkinson’s disease (PwPD). Background: Walking over short…Do improvements to primary symptoms from sensory training differ in Parkinson’s disease ON vs. OFF dopaminergic medications?
Objective: Investigate whether the effects of sensory training differ ON vs. OFF medication in Parkinson’s disease using the Unified Parkinson’s Disease Rating Scale (UPDRS-III). Background:…
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