Age at onset and Parkinson’s disease progression
Objective: Explore whether age at onset of Parkinson’s disease influences the rate of early disease progression. Background: In cross-sectional studies, older age at onset has…An Apparent Cluster of Parkinson’s Disease (PD) in a Golf Community
Objective: Objective: To describe an apparent cluster of PD in a golf community Background: Golf courses may use more pesticides/acre than are employed in agriculture. Certain…Movement disorders in a family carrying ATP7A variant
Objective: To report an early onset parkinsonism in a family carrying a pathogenic variant in the ATP7A gene. Background: ATP7A variants cause Menkes disease (MD), a…HD Constellation: A novel patient-centred approach to enriching clinical datasets by combining medical record chart review and Enroll-HD
Objective: HD Constellation aims to create a dataset providing a longitudinal view of the Huntington’s disease (HD) course, based on physician-provided medical records in the…Pridopidine for the Treatment of Early Huntington’s Disease
Objective: Assess the efficacy of pridopidine 45 mg bid for maintenance of total functional capacity (TFC) and motor function in early HD patients. Background: Pridopidine…The roles of Huntingtin Associated Protein 40 in Huntingtin functions and Huntington’s disease pathogenesis
Objective: Huntington’s disease (HD) is caused by an abnormal expansion of a glutamine tract (polyQ) in huntingtin (HTT), a large scaffold protein with numerous reported…The usefulness of a dual-phase 18-F-FP-CIT PET in a case of Alzheimer’s disease with slow movement
Objective: To think about the usefulness of a dual-phase 18-F-FP-CIT PET in cases of dementia with bradykinesia. Background: A classic 18-F-FP-CIT PET is useful in…Preclinical pharmacology and early clinical development of dopamine D1 positive allosteric modulators (D1PAMs) with therapeutic potential for neuropsychiatric disorders
Objective: The objective was to characterize novel dopamine D1PAMs pre-clinically in behavioral and neurochemical models and in phase 1 human studies in healthy volunteers and…Associations between balance confidence, gait, postural stability, and muscle strength in people with Parkinson’s disease
Objective: This study aimed to investigate the associations between balance confidence and gait difficulty, postural instability, and muscle weakness in people with Parkinson’s disease (PD).…Therapeutic effect of OnabotulinumtoxinA in bilateral hemifacial spasm, trigeminal neuralgia and chronic migraine in El Salvador
Objective: To Evaluate the therapeutic and preventive effect of OnabotulinumtoxinA in the treatment of trigeminal neuralgia (TN) and chronic migraine (CM) in patients with bilateral…
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