Shannon entropy: a novel tool for assessing pentagon drawing in Parkinson’s disease
Objective: We used a digitizing tablet during PCT as a potential tool for assessing early cognitive deficits in PD yet without major cognitive impairment. We…Cognitive-driven ADL impairment as a predictor for PDD
Objective: To evaluate whether Parkinson’s disease (PD) patients with mild activity of daily living (ADL) impairment are at higher risk for developing dementia (PDD). Background:…The Functional Impact of REM Sleep Behavior Disorder in Parkinson’s Disease with Mild Cognitive Impairment
Objective: This study examines whether severity and the functional impact of cognitive decline in Parkinson’s disease mild cognitive impairment (PD MCI) participants differ between those…Interrogating Parkinson’s disease associated mutations at single cell resolution
Objective: To uncover potentially causative Parkinson’s disease (PD) somatic mutations in post-mortem substantia nigra pars compacta (SNpc) tissues from sporadic PD patients using single cell…Utility of the long-read single-molecule nanopore sequencing for detection of repeat number and epigenetic modifications relevant for X-linked dystonia-parkinsonism
Objective: To investigate the utility of long-read single-molecule nanopore sequencing for simultaneous detection of repeat number and methylation of the SINE-VNTR-Alu (SVA) retrotransposon in the…Parkinsonism in individuals with genetic neurodevelopmental disorders: A systematic review
Objective: It is increasingly recognized that individuals with genetic neurodevelopmental disorders (GNDs) such as 22q11.2 deletion syndrome can suffer from parkinsonism. We aim to provide…Lysosomal storage disorder genes variants in Parkinson’s disease: a large cohort study in Chinese mainland population
Objective: In this study, we investigated the association between rare variants in lysosomal storage disorders (LSDs) genes and Parkinson’s disease in large Chinese mainland cohorts.…Impaired glucocerebrosidase transport to lysosomes in cultured macrophages derived from blood monocytic cells of patients with Parkinson’s disease associated with mutations in the GBA gene
Objective: To study the glucocerebrosidase (GCase) activity and translocation to lysosomes in cultured macrophages derived from patient blood monocytic cells (PBMC) of Parkinson's disease patients…α-synuclein and deficits of membrane trafficking in Parkinson’s Disease
Objective: Aim of the study is to understand the physical and functional relationships between the PD-associated protein α-synuclein and some of the Soluble N-ethylmaleimide-sensitive-factor Attachment…Perivascular spaces in the basal ganglia and long-term motor prognosis in newly diagnosed Parkinson’s disease
Objective: To investigate the association between enlarged perivascular spaces (PVSs) in the basal ganglia (BG-PVSs) and long-term motor outcomes in Parkinson’s disease (PD). Background: PVSs…
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