Parkin deficiency impairs mtDNA dynamics and propagates inflammation
Objective: We sought to explore Parkin’s role in (i) averting neuronal mtDNA dyshomeostasis/release and (ii) the activation of downstream inflammatory processes. Background: Mutations in Parkin…Initial Postmarketing Real World Experience with directSTIM™ DBS System: A Case Series
Objective: In this study we report the first three cases of a new, CE-marked system for deep brain stimulation. Background: The PMCF study is a…TWNK in Parkinson’s disease: a Movement Disorder and Mitochondrial Disease Center perspective study
Objective: The aim of the study was to screen for TWNK variants in an Italian cohort of Parkinson’s disease (PD) patients, and to assess the…Involving people with lived experience of Parkinson’s in trial design: the EJS ACT-PD initiative
Objective: To maximally involve people with the lived experience of Parkinson’s in the design of the first multi-arm multi-stage (MAMS) trial for disease modifying therapies…Intraoperative microelectrode recodings reveal functional structure of Globus Pallidus pars interna in dystonic patients
Objective: We characterized the functional structure of Globus pallidus pars interna (GPi) in dystonic patients by analizing the distribution of the firing pattern features in…The functional neuroanatomy of cortical slowing predicts clinical features of Parkinson’s disease
Objective: Investigate the relevance of spatially-resolved estimates of cortical neural slowing for predicting clinical features of patients with Parkinson’s disease (PD). Background: In patients with…Clinical, imaging and genetic characteristics from an Indian ARSACS cohort
Objective: Provide insight into SACS mutations in India, by targeted gene panel of a suspected cohort. Background: Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), caused…Altered brain dynamics in Parkinson’s disease patients treated by deep brain stimulation
Objective: The presented work explores electrophysiological changes in brain dynamics described by EEG microstates and the effect of deep brain stimulation (DBS) of subthalamic nucleus…IgG to neurotensin in blood of Parkinson’s disease patients
Objective: The aim of the study was measurement of IgG to NT in blood plasma of Parkinson's disease patients. Background: Neurotensin (NT) is a 13-amino-acid…Gait declines faster over time in people with Parkinson’s disease converting to a freezing of gait phenotype
Objective: To monitor gait progression in people with Parkinson’s disease (PwPD) who convert from a non-freezing (noFOG) to a freezing of gait (FOG) phenotype. Background:…
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