Mimics or multiplicity: two patients with a PSP phenotype and underlying genetic neurodegenerative disorders.
Objective: To describe a two cases of patients presenting with a PSP phenotype and genetic findings consisted with Huntington’s disease (HD) in one case and…Transcranial magnetic resonance-guided focused ultrasound in Lance-Adams syndrome
Objective: The objective is to present the first reported case of a patient with post-hypoxic myoclonus (PHM) who underwent noninvasive MR-guided Focused Ultrasound Treatment (MRgFUS).…A phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor: KINETIC 2 trial in progress
Objective: The phase 2b KINETIC 2 trial is a double-blind, randomized, placebo-controlled, dose-response study designed to evaluate SAGE-324/BIIB124 (SAGE-324) for the treatment of patients with…Smoking and Substantia Nigra Neuron Density in the Presence and Absence of Lewy Pathology
Objective: Our objective is to examine the association of mid-life smoking with post mortem substantia nigra (SN) neuron density in the presence and absence of…Assessment of novel diffusion MRI metrics of cortical microstructure in the genetic continuum of Parkinson’s disease
Objective: To investigate novel cortical diffusivity metrics in Parkinson’s disease (PD), including both prodromal and established genetic PD, alongside sporadic PD and healthy controls (HC).…Capturing the complexity of patients with parkinsonism: Baseline characteristics of participants in the PRIME-UK cross-sectional study
Objective: This cross-sectional study seeks to describe the symptomatology and health needs of a representative sample of people with parkinsonism, including those living with frailty,…Illusory responses across the Lewy body disease spectrum
Objective: To study pareidolias in patients across the Lewy body disease-spectrum, including those without psychosis. Background: Pareidolias are specific illusions of faces and objects perceived…Dopaminergic medication improves movement vigour in Parkinson’s but not the adaptation of movement speed to curvature
Objective: This study assessed kinematic profiles of individuals with Parkinson’s on and off dopaminergic medication to investigate whether the effect of dopaminergic modulation on speed…Gerstmann-Sträussler-Scheinker disease presenting as dystonia
Objective: Gerstmann-Sträussler-Scheinker disease (GSS) is a type of human transmissible spongiform encephalopathy that is determined genetically. Background: Gerstmann-Sträussler-Scheinker disease (GSS) is a type of human…Determination of glycine transporter 1 levels with [3H]-NFPS binding in hemi-parkinsonian rats with L-DOPA induced dyskinesia
Objective: To determine the distribution of the glycine transporter 1 (GlyT1) in brain areas implicated in parkinsonism and L-3,4-dihydroxyphenylalanine (L-DOPA) induced dyskinesia in the 6-hydroxydopamine…
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