Relationship Between a-syn RT-QuIC and a-syn Neuropathologic Burden in Dementia with Lewy Bodies
Objective: To determine if measures of alpha-synuclein (a-syn) real time quaking induced conversion (RT-QuIC) activity are related to a-syn neuropathologic burden in dementia with Lewy…Intrastriatal injection of alpha-synuclein preformed fibrils results in cognitive dysfunction and L-DOPA reversible sensorimotor impairments in rats
Objective: To determine the effect of intrastriatal injection of alpha-synuclein (aSyn) preformed fibrils (PFFs) on sensorimotor and non-motor function in rats. Background: The ideal animal…Selective α-synuclein overexpression-induced pathology in noradrenergic neurons: a new mouse model for prodromal Parkinson’s disease?
Objective: To investigate the phenotype of noradrenergic (NA) neurons in an animal model with selective overexpression of α-synuclein (αSyn) in the locus coeruleus (LC) with…Characterization of novel alpha-synuclein aggregation model of Parkinson’s disease
Objective: To establish and characterize a robust alpha-synuclein (aSyn) aggregation pathology research model to allow efficient drug development platform for Parkinson's disease (PD). Background: PD…Targeted deep sequencing of brain DNA for detection of somatic point mutations in synucleinopathies
Objective: To detect relevant somatic "point mutations" (single nucleotide variants- SNVs) in brain-derived DNA in synucleinopathies. Background: There is increasing recognition that neurons may harbour…Systematic Assessment of 10 diagnostic marker candidates in biological fluids for Parkinson’s disease
Objective: To validate in serum and/or cerebrospinal fluid (CSF) diagnostic biomarker candidates identified from a systematic literature search including markers on axonal and synaptic integrity,…Amylin deposition in the brain of Parkinson’s disease patients
Objective: The objective of this study was to determine the presence of amylin deposits in the brain of subjects with synucleinopathies. Background: The link between…Ginsenoside Rb1 Prevents MPTP-Induced Changes in Hippocampal Memory via Regulation of the α-Synuclein/PSD-95 Pathway
Objective: To explore the effects of ginsenoside Rb1 on the cognitive impairment of Parkinson’s disease (PD) model. Background: Memory deficiency is a common non-motor symptom…GBA1 biomarkers in longitudinal CSF: GCase, Sphingolipids and alpha-synuclein
Objective: To assess the GBA1-pathway-specific biomarker profile in patient-derived CSF. Background: Heterozygous mutations in the GBA1 gene represent the most common genetic risk factor for…Investigation of the protective efficacy of alpha-synuclein-specific antibodies in a novel neuronal cell model for synucleinopathies
Objective: To investigate the protective efficacy of different alpha-synuclein (α-Syn)-targeting antibodies in a new model of α-Syn cell-to-cell spread. Background: The 14 kDa protein α-Syn…
- « Previous Page
- 1
- …
- 45
- 46
- 47
- 48
- 49
- …
- 70
- Next Page »